Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4ogya_ All beta proteins Trypsin-like serine proteases Trypsin-like serine proteases Eukaryotic proteases automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Bd4ogyb_ All beta proteins Trypsin-like serine proteases Trypsin-like serine proteases Eukaryotic proteases automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth H]d4ogyh_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
E [auth M]d4ogym_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth L]d4ogyl2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth L]d4ogyl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth N]d4ogyn2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
F [auth N]d4ogyn1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATrypsin_1e4ogyA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrel 2F: Trypsin_1ECOD (1.6)
BTrypsin_1e4ogyB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrel 2F: Trypsin_1ECOD (1.6)
C [auth H]C1-set_1e4ogyH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
C [auth H]V-set_12e4ogyH2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
E [auth M]C1-set_1e4ogyM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
E [auth M]V-set_12e4ogyM2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)
D [auth L]C1-set_4e4ogyL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
D [auth L]V-sete4ogyL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
F [auth N]C1-set_4e4ogyN1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
F [auth N]V-sete4ogyN2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
C [auth H],
E [auth M]
DX-2930 VH-CH1 Homo sapiens (human) IGHV3-23*01, IGHV3-23*03, IGHV3-23D*01, IGHJ3*02, IGHG1*03 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-1_KAPPA IMGT (202444-0)
D [auth L],
F [auth N]
DX-2930 L-KAPPA Homo sapiens (human) IGKV1-5*03, IGKJ1*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-1_KAPPA IMGT (202444-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
C [auth H],
E [auth M]
Heavy ChainIGHV3 -plasma kallikreinSAbDab (2024-11-08)
D [auth L],
F [auth N]
Light ChainIGKV1 Kappaplasma kallikreinSAbDab (2024-11-08)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

ChainNameTargetProvenance Source
C [auth H],
E [auth M]
Lanadelumab KLKB1Therapeutic SAbDab (2024-11-08)
D [auth L],
F [auth N]
Lanadelumab KLKB1Therapeutic SAbDab (2024-11-08)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00089Trypsin (Trypsin)Trypsin- Domain
C [auth H],
E [auth M]
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
C [auth H],
E [auth M]
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
D [auth L],
F [auth N]
PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
D [auth L],
F [auth N]
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Plasma kallikrein
C [auth H],
E [auth M]
DX-2930 HEAVY CHAIN
D [auth L],
F [auth N]
DX-2930 LIGHT CHAIN- -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR000177Apple domainDomain
A, B
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B
IPR001314Peptidase S1A, chymotrypsin familyFamily
A, B
IPR033116Serine proteases, trypsin family, serine active siteActive Site
A, B
IPR001254Serine proteases, trypsin domainDomain
A, B
IPR003609PAN/Apple domainDomain
A, B
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A, B
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
C [auth H],
E [auth M]
IPR050199Immunoglobulin Heavy VariableFamily
C [auth H],
E [auth M]
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
C [auth H],
E [auth M]
IPR003597Immunoglobulin C1-setDomain
C [auth H],
E [auth M]
IPR013783Immunoglobulin-like foldHomologous Superfamily
C [auth H],
E [auth M]
IPR013106Immunoglobulin V-set domainDomain
C [auth H],
E [auth M]
IPR003599Immunoglobulin domain subtypeDomain
C [auth H],
E [auth M]
IPR007110Immunoglobulin-like domainDomain
C [auth H],
E [auth M]
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
D [auth L],
F [auth N]
IPR003597Immunoglobulin C1-setDomain
D [auth L],
F [auth N]
IPR050150Immunoglobulin Variable Light ChainFamily
D [auth L],
F [auth N]
IPR013783Immunoglobulin-like foldHomologous Superfamily
D [auth L],
F [auth N]
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
D [auth L],
F [auth N]
IPR013106Immunoglobulin V-set domainDomain
D [auth L],
F [auth N]
IPR003599Immunoglobulin domain subtypeDomain
D [auth L],
F [auth N]
IPR007110Immunoglobulin-like domainDomain
D [auth L],
F [auth N]
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site