4OPG

Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GG-red-SF	e4opgA2	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: FAD-linked reductases-C (From Topology)	T: FAD-linked reductases-C	F: GG-red-SF	ECOD (1.6)
A	FAD_binding_3_1st	e4opgA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: FAD/NAD(P)-binding domain	F: FAD_binding_3_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.50.50.60	Alpha Beta	3-Layer(bba) Sandwich	FAD/NAD(P)-binding domain	FAD/NAD(P)-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01266	FAD dependent oxidoreductase (DAO)	FAD dependent oxidoreductase	This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.	Domain
A	PF22578	Geranylgeranyl reductase catalytic domain (GGR_cat)	Geranylgeranyl reductase catalytic domain	This entry represents the catalytic domain of archaeal geranylgeranyl reductases (GGR) [1-3]. This domain contains the PxxYxWxFP sequence motif, which defines a specificity pocket in the structure, providing a structural basis for the substrate speci ...	This entry represents the catalytic domain of archaeal geranylgeranyl reductases (GGR) [1-3]. This domain contains the PxxYxWxFP sequence motif, which defines a specificity pocket in the structure, providing a structural basis for the substrate specificity of GGRs [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Conserved Archaeal protein	oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-CH group of donors catalytic activity	phospholipid metabolic process organophosphate metabolic process glycerophospholipid metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process primary metabolic process metabolic process cellular process phosphorus metabolic process lipid metabolic process lipid biosynthetic process phospholipid biosynthetic process biosynthetic process organophosphate biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050407	Geranylgeranyl Reductase	Family
A	IPR011777	Geranylgeranyl reductase family	Family
A	IPR006076	FAD dependent oxidoreductase	Domain
A	IPR036188	FAD/NAD(P)-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.