Annotations: 4OSX

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	(Glycosyl)asparaginase	8099985	4002269	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Class II glutamine amidotransferases	8099986	3000131	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Class II glutamine amidotransferases	8099986	3000131	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Asparaginase_2	e4osxA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: (Glycosyl)asparaginase	F: Asparaginase_2	ECOD (1.6)
B	Asparaginase_2	e4osxB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: (Glycosyl)asparaginase	F: Asparaginase_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01112	Asparaginase (Asparaginase_2)	Asparaginase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Isoaspartyl peptidase/L-asparaginase	asparaginase activity amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds peptidase activity omega peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity beta-aspartyl-peptidase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process catabolic process oxoacid metabolic process glutamine family amino acid catabolic process aspartate family amino acid metabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process asparagine catabolic process proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process catabolic process oxoacid metabolic process glutamine family amino acid catabolic process aspartate family amino acid metabolic process amino acid metabolic process organic acid metabolic process organic acid catabolic process asparagine catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process aspartate family amino acid catabolic process carboxylic acid metabolic process L-amino acid catabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process asparagine metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process asparagine catabolic process via L-aspartate small molecule catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol photoreceptor inner segment membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A, B	IPR000246	Peptidase T2, asparaginase 2	Family
A, B	IPR033844	Asparaginase-like 1, metazoa	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q7L266	allergic contact dermatitis Crohn disease large cell medulloblastoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis astrocytic tumor glioblastoma lung cancer malignant mesothelioma osteosarcoma pilocytic astrocytoma ulcerative colitis atypical teratoid rhabdoid tumor allergic contact dermatitis Crohn disease large cell medulloblastoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis astrocytic tumor glioblastoma lung cancer malignant mesothelioma osteosarcoma pilocytic astrocytoma ulcerative colitis atypical teratoid rhabdoid tumor interstitial cystitis malignant ependymoma medulloblastoma ovarian cancer psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.