Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRibonuclease H-like 8075088 3000143 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyRibonuclease H-like 8075088 3000143 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARVT_thumbe4q0bA3 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
ARVT_1e4q0bA4 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
ARNase_He4q0bA2 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
ARVT_connecte4q0bA1 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
CRVT_thumbe4q0bC3 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
CRVT_1e4q0bC4 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
CRNase_He4q0bC2 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)
CRVT_connecte4q0bC1 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
BRVT_thumbe4q0bB2 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
BRVT_1e4q0bB1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
BRVT_connecte4q0bB3 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)
DRVT_thumbe4q0bD2 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: RVT_thumbECOD (1.6)
DRVT_1e4q0bD1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: RVT_1ECOD (1.6)
DRVT_connecte4q0bD3 A: mixed a+b and a/bX: Ribonuclease H-likeH: RNaseH-like domain in reverse transcriptase (From Topology)T: RNaseH-like domain in reverse transcriptaseF: RVT_connectECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
A, C
PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
A, C
PF00075RNase H (RNase_H)RNase HRNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.Domain
A, C
PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain
B, D
PF06817Reverse transcriptase thumb domain (RVT_thumb)Reverse transcriptase thumb domainThis domain is known as the thumb domain. It is composed of a four helix bundle [1].Domain
B, D
PF06815Reverse transcriptase connection domain (RVT_connect)Reverse transcriptase connection domainThis domain is known as the connection domain. This domain lies between the thumb and palm domains [1].Domain
B, D
PF00078Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)Reverse transcriptase (RNA-dependent DNA polymerase)A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
HIV-1 reverse transcriptase, p66 subunit
B, D
HIV-1 reverse transcriptase, p51 subunit
E [auth T],
H [auth E]
5'-R(*AP*UP*GP*GP*UP*CP*GP*GP*CP*GP*CP*CP*CP*G)-3'---
F [auth t],
J [auth e]
5'-R(P*AP*CP*AP*GP*GP*GP*AP*CP*UP*GP*UP*G)-3'---
G [auth P],
I [auth F]
5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*G)-3'---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C
IPR036397Ribonuclease H superfamilyHomologous Superfamily
A, C
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
A, C
IPR001995Peptidase A2A, retrovirus, catalyticDomain
A, C
IPR001878Zinc finger, CCHC-typeDomain
A, C
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
A, C
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
A, C
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
A, C
IPR018061RetropepsinsDomain
A, C
IPR010661Reverse transcriptase thumbDomain
A, C
IPR002156Ribonuclease H domainDomain
A, C
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
A, C
IPR003308Integrase, N-terminal zinc-binding domainDomain
A, C
IPR001584Integrase, catalytic coreDomain
A, C
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
A, C
IPR010999Retroviral matrix proteinHomologous Superfamily
A, C
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
A, C
IPR001969Aspartic peptidase, active siteActive Site
A, C
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
A, C
IPR017856Integrase-like, N-terminalHomologous Superfamily
A, C
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
A, C
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, C
IPR001037Integrase, C-terminal, retroviralDomain
A, C
IPR034170Retropepsin-like catalytic domainDomain
A, C
IPR000477Reverse transcriptase domainDomain
A, C
IPR010659Reverse transcriptase connectionDomain
A, C
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily
B, D
IPR036397Ribonuclease H superfamilyHomologous Superfamily
B, D
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
B, D
IPR001995Peptidase A2A, retrovirus, catalyticDomain
B, D
IPR001878Zinc finger, CCHC-typeDomain
B, D
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
B, D
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
B, D
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
B, D
IPR018061RetropepsinsDomain
B, D
IPR010661Reverse transcriptase thumbDomain
B, D
IPR002156Ribonuclease H domainDomain
B, D
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
B, D
IPR003308Integrase, N-terminal zinc-binding domainDomain
B, D
IPR001584Integrase, catalytic coreDomain
B, D
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
B, D
IPR010999Retroviral matrix proteinHomologous Superfamily
B, D
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
B, D
IPR001969Aspartic peptidase, active siteActive Site
B, D
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
B, D
IPR017856Integrase-like, N-terminalHomologous Superfamily
B, D
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
B, D
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
B, D
IPR001037Integrase, C-terminal, retroviralDomain
B, D
IPR034170Retropepsin-like catalytic domainDomain
B, D
IPR000477Reverse transcriptase domainDomain
B, D
IPR010659Reverse transcriptase connectionDomain
B, D
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily