4QNQ

Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bcl-2	e4qnqA1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
B	Bcl-2	e4qnqB1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
C	Bcl-2	e4qnqC1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
D	Bcl-2	e4qnqD1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
E	Bcl-2	e4qnqE1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
F	Bcl-2	e4qnqF1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
G	Bcl-2	e4qnqG1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
H	Bcl-2	e4qnqH1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
I	Bcl-2	e4qnqI1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
J	Bcl-2	e4qnqJ1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
K	Bcl-2	e4qnqK1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)
L	Bcl-2	e4qnqL1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: Bcl-2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
B	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
C	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
D	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
E	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
F	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
G	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
H	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
I	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
J	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
K	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
L	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF02180	Bcl-2 homology region 4 (BH4)	Bcl-2 homology region 4	-	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Bcl-2-like protein 1	death domain binding protein binding binding BH3 domain binding BH domain binding protein domain specific binding protein-containing complex binding clathrin binding MDM2/MDM4 family protein binding enzyme binding GTPase binding enzyme regulator activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular function regulator activity death domain binding protein binding binding BH3 domain binding BH domain binding protein domain specific binding protein-containing complex binding clathrin binding MDM2/MDM4 family protein binding enzyme binding GTPase binding enzyme regulator activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular function regulator activity cysteine-type endopeptidase regulator activity involved in apoptotic process kinase binding protein kinase binding identical protein binding	response to stimulus response to chemical response to xenobiotic stimulus response to stress response to ischemia cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway response to stimulus response to chemical response to xenobiotic stimulus response to stress response to ischemia cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process signal transduction regulation of biological process regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication cellular process apoptotic process programmed cell death regulation of apoptotic signaling pathway response to radiation response to abiotic stimulus regulation of localization apoptotic mitochondrial changes localization regulation of biological quality positive regulation of membrane permeability negative regulation of cellular component organization establishment of localization regulation of organelle organization regulation of membrane permeability negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability involved in apoptotic process regulation of cellular component organization negative regulation of mitochondrial membrane permeability transport mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization cellular component organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability cellular component organization or biogenesis regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization regulation of transport organelle organization negative regulation of organelle organization regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrion organization negative regulation of membrane permeability mitochondrial outer membrane permeabilization import into cell cellular localization synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell regulation of endocytosis synaptic vesicle endocytosis regulation of vesicle-mediated transport endocytosis apoptotic process in bone marrow cell response to peptide response to cytokine response to erythropoietin developmental process cellular developmental process reproductive process cell development developmental process involved in reproduction programmed cell death involved in cell development cell differentiation anatomical structure development ectopic germ cell programmed cell death positive regulation of cell communication regulated exocytosis positive regulation of neurotransmitter secretion synaptic vesicle exocytosis positive regulation of regulated secretory pathway trans-synaptic signaling positive regulation of neurotransmitter transport neurotransmitter secretion regulation of synaptic vesicle exocytosis positive regulation of synaptic transmission neurotransmitter transport regulation of secretion signal release from synapse regulation of trans-synaptic signaling exocytosis modulation of chemical synaptic transmission positive regulation of biological process positive regulation of secretion by cell positive regulation of exocytosis regulation of regulated secretory pathway synaptic signaling regulation of secretion by cell secretion by cell positive regulation of secretion signal release positive regulation of cellular process positive regulation of synaptic vesicle exocytosis secretion regulation of neurotransmitter transport export from cell cell-cell signaling chemical synaptic transmission positive regulation of transport regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of exocytosis positive regulation of signaling cellular response to chemical stimulus cellular response to xenobiotic stimulus response to ketone response to cycloheximide response to alcohol response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to hydrogen peroxide response to oxidative stress response to reactive oxygen species cellular response to interleukin-1 cellular response to cytokine stimulus response to interleukin-1 cellular response to stress response to endoplasmic reticulum stress sexual reproduction multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism gamete generation germ cell development regulation of mitochondrial membrane potential regulation of membrane potential negative regulation of intracellular signal transduction regulation of cellular response to stress regulation of response to endoplasmic reticulum stress negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of intrinsic apoptotic signaling pathway intracellular signal transduction regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of intracellular signal transduction regulation of response to stress intrinsic apoptotic signaling pathway negative regulation of response to endoplasmic reticulum stress negative regulation of intrinsic apoptotic signaling pathway vesicle localization synaptic vesicle clustering organelle localization positive regulation of synaptic vesicle clustering regulation of synaptic vesicle clustering synaptic vesicle localization regulation of developmental process negative regulation of developmental process regulation of leukocyte apoptotic process dendritic cell apoptotic process negative regulation of dendritic cell apoptotic process leukocyte apoptotic process negative regulation of leukocyte apoptotic process regulation of dendritic cell apoptotic process cellular response to tumor necrosis factor response to tumor necrosis factor response to metal ion response to lead ion cell population proliferation epithelial cell proliferation hepatocyte apoptotic process epithelial cell apoptotic process neuron apoptotic process negative regulation of synaptic transmission regulation of synaptic plasticity long-term synaptic depression regulation of long-term synaptic depression biological process involved in interspecies interaction between organisms response to lipid response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin positive regulation of cellular component organization positive regulation of synaptic vesicle recycling positive regulation of endocytosis positive regulation of synaptic vesicle endocytosis multicellular organismal process gonad development reproductive system development sex differentiation animal organ development male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development system development spermatogenesis male gamete generation mononuclear cell proliferation dendritic cell proliferation leukocyte proliferation fertilization response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to hypoxia response to oxygen levels regulation of growth growth positive regulation of programmed cell death positive regulation of apoptotic process cellular response to erythropoietin cellular response to nitrogen compound cellular response to alkaloid response to alkaloid cellular response to endogenous stimulus response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus response to endogenous stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to lipid response to dexamethasone embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development response to electrical stimulus signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand negative regulation of reproductive process regulation of reproductive process regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process head development forebrain development brain development nervous system development pallium development cerebral cortex development central nervous system development telencephalon development female gonad development female sex differentiation development of primary female sexual characteristics ovarian follicle development regulation of release of cytochrome c from mitochondria negative regulation of release of cytochrome c from mitochondria release of cytochrome c from mitochondria cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid regulation of leukocyte proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation positive regulation of mononuclear cell proliferation regulation of mononuclear cell proliferation nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process positive regulation of phosphate metabolic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process ribonucleotide biosynthetic process purine nucleoside triphosphate biosynthetic process regulation of small molecule metabolic process positive regulation of purine nucleotide biosynthetic process regulation of phosphate metabolic process regulation of nucleotide metabolic process phosphate-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process regulation of metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process positive regulation of nucleotide metabolic process positive regulation of cellular metabolic process purine nucleotide metabolic process ribonucleotide metabolic process positive regulation of biosynthetic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine-containing compound biosynthetic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process regulation of biosynthetic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process organophosphate metabolic process positive regulation of small molecule metabolic process regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage DNA damage response cellular response to nitric oxide response to nitric oxide cellular response to reactive nitrogen species response to peptide hormone protein localization regulation of protein localization negative regulation of protein localization to plasma membrane cellular macromolecule localization regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization macromolecule localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation cellular response to abiotic stimulus response to gamma radiation response to organophosphorus response to purine-containing compound response to cAMP cellular response to cAMP negative regulation of neuron apoptotic process regulation of neuron apoptotic process intracellular transport endosomal transport synaptic vesicle endosomal processing synaptic vesicle recycling via endosome cellular response to astaxanthin response to astaxanthin negative regulation of execution phase of apoptosis regulation of execution phase of apoptosis execution phase of apoptosis cellular response to prolactin response to prolactin cellular response to peptide hormone stimulus response to virus	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol transport vesicle synapse intracellular vesicle presynapse cytoplasmic vesicle synaptic vesicle cell junction secretory vesicle vesicle exocytic vesicle mitochondrial membrane organelle inner membrane mitochondrion mitochondrial inner membrane mitochondrial envelope protein-containing complex Bcl-2 family protein complex membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen organelle outer membrane bounding membrane of organelle mitochondrial outer membrane outer membrane transport vesicle membrane vesicle membrane synaptic vesicle membrane exocytic vesicle membrane cytoplasmic vesicle membrane centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR020731	Apoptosis regulator, Bcl-2, BH4 motif, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR004725	Apoptosis regulator, Bcl-2/ BclX	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR002475	Bcl2-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013279	Apoptosis regulator, Bcl-X	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR026298	Bcl-2 family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.