Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4reqa1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Cobalamin (vitamin B12)-dependent enzymes Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain Methylmalonyl-CoA mutase alpha subunit, domain 1 (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Ad4reqa2 Alpha and beta proteins (a/b) Flavodoxin-like Cobalamin (vitamin B12)-binding domain Cobalamin (vitamin B12)-binding domain Methylmalonyl-CoA mutase alpha subunit, C-terminal domain (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Cd4reqc1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Cobalamin (vitamin B12)-dependent enzymes Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain Methylmalonyl-CoA mutase alpha subunit, domain 1 (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Cd4reqc2 Alpha and beta proteins (a/b) Flavodoxin-like Cobalamin (vitamin B12)-binding domain Cobalamin (vitamin B12)-binding domain Methylmalonyl-CoA mutase alpha subunit, C-terminal domain (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Bd4reqb1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Cobalamin (vitamin B12)-dependent enzymes Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain Methylmalonyl-CoA mutase beta subunit, domain 1 (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Bd4reqb2 Alpha and beta proteins (a/b) Flavodoxin-like Cobalamin (vitamin B12)-binding domain Cobalamin (vitamin B12)-binding domain Methylmalonyl-CoA mutase beta subunit, C-terminal domain (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Dd4reqd1 Alpha and beta proteins (a/b) TIM beta/alpha-barrel Cobalamin (vitamin B12)-dependent enzymes Methylmalonyl-CoA mutase, N-terminal (CoA-binding) domain Methylmalonyl-CoA mutase beta subunit, domain 1 (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)
Dd4reqd2 Alpha and beta proteins (a/b) Flavodoxin-like Cobalamin (vitamin B12)-binding domain Cobalamin (vitamin B12)-binding domain Methylmalonyl-CoA mutase beta subunit, C-terminal domain (Propionibacterium freudenreichii subsp. shermanii ) [TaxId: 1752 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043843 3000609 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044101 3001260 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044101 3001260 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043843 3000609 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043845 3000609 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044102 3001260 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044102 3001260 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043845 3000609 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMM_CoA_mutasee4reqA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
AB12-bindinge4reqA2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)
CMM_CoA_mutasee4reqC1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
CB12-bindinge4reqC2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)
BMM_CoA_mutasee4reqB1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
BmmCoA_mut_betae4reqB2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: mmCoA_mut_betaECOD (1.6)
DMM_CoA_mutasee4reqD1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
DmmCoA_mut_betae4reqD2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: mmCoA_mut_betaECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF02310B12 binding domain (B12-binding)B12 binding domainThis domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, ...This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2].
Domain
A, C
PF01642Methylmalonyl-CoA mutase (MM_CoA_mutase)Methylmalonyl-CoA mutase- Family
B, D
PF01642Methylmalonyl-CoA mutase (MM_CoA_mutase)Methylmalonyl-CoA mutase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
METHYLMALONYL-COA MUTASE
B, D
METHYLMALONYL-COA MUTASE