Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCysteine proteinases 8091720 3001808 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPLpro Zn-binding domain-like 8091721 3002538 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCysteine proteinases 8091720 3001808 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyUbiquitin-like 8091722 3000157 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AViral_protease_Ne4rezA2 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Viral_protease_NECOD (1.6)
AViral_protease_Ce4rezA1 A: a+b complex topologyX: Cysteine proteinases-likeH: Cysteine proteinases (From Topology)T: Cysteine proteinasesF: Viral_protease_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.20.540 Alpha Beta Roll Ubiquitin-like (UB roll) Papain-like viral protease, N-terminal domainCATH (4.3.0)
A1.10.8.1190 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
A2.60.120.1680 Mainly Beta Sandwich Jelly Rolls CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ORF1ab protein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
IPR044315Nonstructural protein 14, betacoronavirusDomain
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
IPR046441RNA-dependent RNA polymerase, coronavirusDomain
IPR044388Non-structural protein 2, MERS-CoV-likeDomain
IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR013016Peptidase C16, coronavirusDomain
IPR009466Non-structural protein 14, coronavirusDomain
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
IPR047570NSP12, interface domain, coronavirusDomain
IPR018995RNA synthesis protein NSP10, coronavirusDomain
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
IPR050534Coronaviruses polyprotein 1abFamily
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
IPR044350RNA-dependent RNA polymerase, Middle East respiratory syndrome-related coronavirusDomain
IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
IPR014828Non-structural protein NSP7, coronavirusDomain
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
IPR014829Non-structural protein NSP8, coronavirusDomain
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR008740Peptidase C30, coronavirusDomain
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
IPR049894Coronavirus NSP3, 3Ecto domainDomain
IPR043472Macro domain-likeHomologous Superfamily
IPR043609NendoU domain, nidovirusDomain
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
IPR043611Coronavirus replicase NSP3, C-terminalDomain
IPR047566Coronavirus replicase NSP3, Y domainDomain
IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
IPR044382NSP3, SUD-C domain, MERS-CoV-likeDomain
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
IPR043610Non-structural protein 6, coronavirusDomain
IPR027351(+) RNA virus helicase core domainDomain
IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
IPR009461Non-structural protein NSP16, coronavirus-likeDomain
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
IPR014822Non-structural protein NSP9, coronavirusDomain
IPR021590NSP1, globular domain, betacoronavirusDomain
IPR044367Non-structural protein 6, betacoronavirusDomain
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
IPR046438Nidovirus 2-O-methyltransferaseDomain
IPR002589Macro domainDomain
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
IPR044371Non-structural protein 3, X-domain-likeDomain
IPR007094RNA-directed RNA polymerase, catalytic domainDomain