4U0T

Crystal structure of ADC-7 beta-lactamase


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4u0ta_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Bd4u0tb_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Cd4u0tc_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Dd4u0td_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Ed4u0te_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Fd4u0tf_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Gd4u0tg_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)
Hd4u0th_ Multi-domain proteins (alpha and beta) beta-lactamase/transpeptidase-like beta-lactamase/transpeptidase-like automated matches automated matches (Acinetobacter baumannii ) [TaxId: 470 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
BSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
CSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
DSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
ESCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
FSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
GSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)
HSCOP2B Superfamilybeta-lactamase/transpeptidase-like 8069923 3001604 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ABeta-lactamase_1ste4u0tA2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
ABeta-lactamase_2nde4u0tA1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
BBeta-lactamase_1ste4u0tB2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
BBeta-lactamase_2nde4u0tB1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
CBeta-lactamase_1ste4u0tC2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
CBeta-lactamase_2nde4u0tC1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
DBeta-lactamase_1ste4u0tD2 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
DBeta-lactamase_2nde4u0tD1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
EBeta-lactamase_1ste4u0tE1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
EBeta-lactamase_2nde4u0tE2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
FBeta-lactamase_1ste4u0tF1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
FBeta-lactamase_2nde4u0tF2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
GBeta-lactamase_1ste4u0tG1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
GBeta-lactamase_2nde4u0tG2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)
HBeta-lactamase_1ste4u0tH1 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_1stECOD (1.6)
HBeta-lactamase_2nde4u0tH2 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Beta-lactamase_2ndECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C, D, E
ARO:3003853ADC-7ADC-7 is a beta-lactamase that is found in Acinetobacter baumannii.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D, E
ARO:3003846ADC beta-lactamase without carbapenemase activitycephalosporinantibiotic inactivationCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00144Beta-lactamase (Beta-lactamase)Beta-lactamaseThis family appears to be distantly related to Pfam:PF00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR001466Beta-lactamase-relatedDomain
A, B, C, D, E
IPR012338Beta-lactamase/transpeptidase-likeHomologous Superfamily
A, B, C, D, E
IPR001586Beta-lactamase, class-C active siteActive Site
A, B, C, D, E
IPR050491Bacterial Cell Wall Synthesis and ModificationFamily