Annotations: 4XGR

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth E]	PIN	e4xgrE1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PIN	ECOD (1.6)
A	PIN	e4xgrA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PIN	ECOD (1.6)
B [auth G]	PIN	e4xgrG1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PIN	ECOD (1.6)
D [auth C]	PIN	e4xgrC1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: PIN domain-like	F: PIN	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth E]	3.40.50.1010	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	5'-nuclease	CATH (4.3.0)
A	3.40.50.1010	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	5'-nuclease	CATH (4.3.0)
B [auth G]	3.40.50.1010	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	5'-nuclease	CATH (4.3.0)
D [auth C]	3.40.50.1010	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	5'-nuclease	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth G], C [auth E], D [auth C]	PF01850	PIN domain (PIN)	PIN domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth G], C [auth E], D [auth C]	Ribonuclease VapC30	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	regulation of biological process regulation of growth negative regulation of growth negative regulation of biological process biological regulation growth	-
E [auth B], F [auth H], G [auth F], H [auth D]	Antitoxin VapB30	-	positive regulation of growth regulation of biological process regulation of growth positive regulation of biological process biological regulation growth	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth G], C [auth E], D [auth C]	IPR002716	PIN domain	Domain
A, B [auth G], C [auth E], D [auth C]	IPR029060	PIN-like domain superfamily	Homologous Superfamily
A, B [auth G], C [auth E], D [auth C]	IPR022907	VapC family	Family
A, B [auth G], C [auth E], D [auth C]	IPR050556	Type II toxin-antitoxin system RNase	Family
E [auth B], F [auth H], G [auth F], H [auth D]	IPR011660	Antitoxin VapB-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.