Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AEUF07928e4xj4A1 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: PAP/OAS1 substrate-binding domainF: EUF07928ECOD (1.6)
ANT_2-5OAS_ClassI-CCAase_likee4xj4A2 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: NT_2-5OAS_ClassI-CCAase_likeECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF21713Cyclic GMP-AMP synthase, C-terminal domain (DncV_C)Cyclic GMP-AMP synthase, C-terminal domainThis domain is found Cyclic GMP-AMP synthase from Vibrio cholerae (DncV), a prokaryotic cGAS-like enzyme that synthesises cyclic GMP- AMP (c-GAMP) and stimulates intestinal colonization. DncV adopts a structure and topology that are typical of the n ...This domain is found Cyclic GMP-AMP synthase from Vibrio cholerae (DncV), a prokaryotic cGAS-like enzyme that synthesises cyclic GMP- AMP (c-GAMP) and stimulates intestinal colonization. DncV adopts a structure and topology that are typical of the nucleotidyltransferase superfamily. It is organised into two domains: an N-terminal domain that contains the catalytic loop (Pfam:PF21654) and a C- terminal helix bundle that consists of eight helices and one pair of anti-parallel beta-sheets (this entry) [1-3].
Domain
PF21654Cyclic GMP-AMP synthase DncV-like, nucleotidyltransferase domain (DncV-like_NTFase)Cyclic GMP-AMP synthase DncV-like, nucleotidyltransferase domainThis is the nucleotidyltransferase domain of DncV from Vibrio cholerae (also known as Cyclic GMP-AMP synthase) and related proteins [1-4]. DncV catalyses the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP. It is part of the CBASS (cyc ...This is the nucleotidyltransferase domain of DncV from Vibrio cholerae (also known as Cyclic GMP-AMP synthase) and related proteins [1-4]. DncV catalyses the synthesis of 3'3'-cyclic GMP-AMP (3'3'-cGAMP) from GTP and ATP. It is part of the CBASS (cyclic oligonucleotide-based antiphage signaling system) which provides immunity against bacteriophage [1-4]. This protein is required for efficient V.cholerae intestinal colonization and and down-regulates the colonization-influencing process of chemotaxis.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Cyclic AMP-GMP synthase -