4XZN

Crystal structure of the methylated K125R/V301L AKR1B10 Holoenzyme

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth X]	d4xznx_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	Aldo-keto reductases (NADP)	Aldose reductase (aldehyde reductase)	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth X]	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8061987	3000288	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	Aldo_ket_red	e4xznX1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF00248	Aldo/keto reductase family (Aldo_ket_red)	Aldo/keto reductase family	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	Aldo-keto reductase family 1 member B10	aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity alcohol dehydrogenase (NADP+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors retinal dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor indanol dehydrogenase activity geranylgeranyl reductase activity aldose reductase (NADPH) activity all-trans-retinol dehydrogenase (NADP+) activity aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity alcohol dehydrogenase (NADP+) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors retinal dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor indanol dehydrogenase activity geranylgeranyl reductase activity aldose reductase (NADPH) activity all-trans-retinol dehydrogenase (NADP+) activity allyl-alcohol dehydrogenase activity	cellular response to stimulus cellular detoxification response to stimulus detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to toxic substance cellular detoxification of aldehyde cellular response to chemical stimulus cellular response to aldehyde response to chemical cellular process cellular response to toxic substance polyprenol metabolic process cellular response to stimulus cellular detoxification response to stimulus detoxification response to oxygen-containing compound cellular response to oxygen-containing compound response to toxic substance cellular detoxification of aldehyde cellular response to chemical stimulus cellular response to aldehyde response to chemical cellular process cellular response to toxic substance polyprenol metabolic process isoprenoid catabolic process catabolic process alcohol catabolic process organic hydroxy compound metabolic process alcohol metabolic process farnesol catabolic process cellular lipid catabolic process cellular catabolic process farnesol metabolic process small molecule metabolic process sesquiterpenoid catabolic process lipid catabolic process primary alcohol catabolic process cellular metabolic process sesquiterpenoid metabolic process primary metabolic process terpenoid catabolic process organic hydroxy compound catabolic process cellular lipid metabolic process metabolic process small molecule catabolic process polyprenol catabolic process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process primary alcohol metabolic process glycosyl compound metabolic process daunorubicin metabolic process polyketide metabolic process glycoside metabolic process carbohydrate derivative metabolic process secondary metabolic process cellular ketone metabolic process aminoglycoside antibiotic metabolic process doxorubicin metabolic process tertiary alcohol metabolic process diterpenoid metabolic process retinoid metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular region cytosol lytic vacuole vacuole lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR018170	Aldo/keto reductase, conserved site	Conserved Site
A [auth X]	IPR020471	Aldo-keto reductase	Family
A [auth X]	IPR036812	NADP-dependent oxidoreductase domain superfamily	Homologous Superfamily
A [auth X]	IPR023210	NADP-dependent oxidoreductase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth X]	Pharos: O60218	melanoma Neoplasm Invasiveness colorectal cancer contact dermatitis cancer endometrial carcinoma large cell medulloblastoma lung cancer malignant pancreatic neoplasm atopic eczema pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic obstructive pulmonary disease sinusitis cutaneous melanoma diabetic neuropathy melanoma Neoplasm Invasiveness colorectal cancer contact dermatitis cancer endometrial carcinoma large cell medulloblastoma lung cancer malignant pancreatic neoplasm atopic eczema pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic obstructive pulmonary disease sinusitis cutaneous melanoma diabetic neuropathy hypertensive disorder malignant colon neoplasm benign neoplasm pancreatic intraductal papillary-mucinous carcinoma pituitary cancer ulcerative colitis cystic fibrosis endometrial cancer head and neck cancer interstitial cystitis lung adenocarcinoma malignant mesothelioma nasopharyngeal carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis colorectal carcinoma hepatocellular carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A [auth X]	MLY	Parent Component: LYS RESID: AA0075 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084
A [auth X]	MLZ	Parent Component: LYS RESID: AA0075 , AA0076 PSI-MOD : N6,N6-dimethyl-L-lysine MOD:00084 , N6-methyl-L-lysine MOD:00085

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.