Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASucc_DH_flav_Ce4yszA3 A: alpha bundlesX: Spectrin repeat-likeH: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domainF: Succ_DH_flav_CECOD (1.6)
AFAD_binding_2e4yszA2 A: a+b complex topologyX: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domainF: FAD_binding_2ECOD (1.6)
AFAD_binding_3_1ste4yszA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: FAD_binding_3_1stECOD (1.6)
ESucc_DH_flav_Ce4yszE3 A: alpha bundlesX: Spectrin repeat-likeH: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domainF: Succ_DH_flav_CECOD (1.6)
EFAD_binding_2e4yszE2 A: a+b complex topologyX: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)H: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain (From Topology)T: Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domainF: FAD_binding_2ECOD (1.6)
EFAD_binding_3_1ste4yszE1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: FAD/NAD(P)-binding domainF: FAD_binding_3_1stECOD (1.6)
BFer4_8e4yszB2 A: alpha arraysX: alpha-helical ferredoxin-likeH: alpha-helical ferredoxin (From Topology)T: alpha-helical ferredoxinF: Fer4_8ECOD (1.6)
BFer2_3e4yszB1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2_3ECOD (1.6)
FFer4_8e4yszF2 A: alpha arraysX: alpha-helical ferredoxin-likeH: alpha-helical ferredoxin (From Topology)T: alpha-helical ferredoxinF: Fer4_8ECOD (1.6)
FFer2_3e4yszF1 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2_3ECOD (1.6)
CSdh_cyte4yszC1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: Sdh_cytECOD (1.6)
GSdh_cyte4yszG1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: Sdh_cytECOD (1.6)
DCybSe4yszD1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: CybSECOD (1.6)
HCybSe4yszH1 A: alpha bundlesX: Transmembrane heme-binding four-helical bundle (From Homology)H: Transmembrane heme-binding four-helical bundleT: Fumarate reductase respiratory complex transmembrane subunitsF: CybSECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.50.50.60 Alpha Beta 3-Layer(bba) Sandwich FAD/NAD(P)-binding domain FAD/NAD(P)-binding domainCATH (4.3.0)
A3.90.700.10 Alpha Beta Alpha-Beta Complex Flavocytochrome C3 Chain A, domain 1CATH (4.3.0)
A1.20.58.100 Mainly Alpha Up-down Bundle Methane Monooxygenase Hydroxylase Chain G, domain 1CATH (4.3.0)
A4.10.80.40 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 succinate dehydrogenase protein domainCATH (4.3.0)
E3.50.50.60 Alpha Beta 3-Layer(bba) Sandwich FAD/NAD(P)-binding domain FAD/NAD(P)-binding domainCATH (4.3.0)
E3.90.700.10 Alpha Beta Alpha-Beta Complex Flavocytochrome C3 Chain A, domain 1CATH (4.3.0)
E1.20.58.100 Mainly Alpha Up-down Bundle Methane Monooxygenase Hydroxylase Chain G, domain 1CATH (4.3.0)
E4.10.80.40 Few Secondary Structures Irregular Rhinovirus 14, subunit 4 succinate dehydrogenase protein domainCATH (4.3.0)
B3.10.20.30 Alpha Beta Roll Ubiquitin-like (UB roll) Beta-grasp domainCATH (4.3.0)
B1.10.1060.10 Mainly Alpha Orthogonal Bundle Fumarate Reductase Iron-sulfur Protein Chain B, domain 2CATH (4.3.0)
F3.10.20.30 Alpha Beta Roll Ubiquitin-like (UB roll) Beta-grasp domainCATH (4.3.0)
F1.10.1060.10 Mainly Alpha Orthogonal Bundle Fumarate Reductase Iron-sulfur Protein Chain B, domain 2CATH (4.3.0)
C1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)
G1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)
D1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)
H1.20.1300.10 Mainly Alpha Up-down Bundle 3 helical TM bundles of succinate and fumarate reductases Fumarate reductase/succinate dehydrogenase, transmembrane subunitCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, E
PF02910Fumarate reductase flavoprotein C-term (Succ_DH_flav_C)Fumarate reductase flavoprotein C-termThis family contains fumarate reductases, succinate dehydrogenases and L-aspartate oxidases.Domain
A, E
PF00890FAD binding domain (FAD_binding_2)FAD binding domain- Family
B, F
PF130852Fe-2S iron-sulfur cluster binding domain (Fer2_3)2Fe-2S iron-sulfur cluster binding domainThe 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which abeta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated.Domain
B, F
PF135344Fe-4S dicluster domain (Fer4_17)4Fe-4S dicluster domainThis family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.Domain
C, G
PF01127Succinate dehydrogenase/Fumarate reductase transmembrane subunit (Sdh_cyt)Succinate dehydrogenase/Fumarate reductase transmembrane subunit- Family
D, H
PF05328CybS, succinate dehydrogenase cytochrome B small subunit (CybS)CybS, succinate dehydrogenase cytochrome B small subunit- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, E
Succinate dehydrogenase flavoprotein
B, F
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
C, G
Cytochrome b-large subunit
D, H
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, E
IPR015939Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminalDomain
A, E
IPR003952Fumarate reductase/succinate dehydrogenase, FAD-binding siteBinding Site
A, E
IPR037099Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamilyHomologous Superfamily
A, E
IPR036188FAD/NAD(P)-binding domain superfamilyHomologous Superfamily
A, E
IPR003953FAD-dependent oxidoreductase 2, FAD binding domainDomain
A, E
IPR030664FAD-dependent oxidoreductase SdhA/FrdA/AprAFamily
A, E
IPR027477Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamilyHomologous Superfamily
A, E
IPR014006Succinate dehydrogenase/fumarate reductase, flavoprotein subunitFamily
A, E
IPR011281Succinate dehydrogenase, flavoprotein subunitFamily
B, F
IPR025192Succinate dehydogenase/fumarate reductase N-terminalDomain
B, F
IPR0360102Fe-2S ferredoxin-like superfamilyHomologous Superfamily
B, F
IPR0010412Fe-2S ferredoxin-type iron-sulfur binding domainDomain
B, F
IPR0060582Fe-2S ferredoxin, iron-sulphur binding siteBinding Site
B, F
IPR004489Succinate dehydrogenase/fumarate reductase iron-sulphur proteinFamily
B, F
IPR009051Alpha-helical ferredoxinHomologous Superfamily
B, F
IPR050573Succinate Dehydrogenase/Fumarate Reductase Iron-SulfurFamily
B, F
IPR0179004Fe-4S ferredoxin, iron-sulphur binding, conserved siteConserved Site
B, F
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainDomain
B, F
IPR012675Beta-grasp domain superfamilyHomologous Superfamily
C, G
IPR018495Succinate dehydrogenase, cytochrome b subunit, conserved siteConserved Site
C, G
IPR034804Fumarate reductase/succinate dehydrogenase, transmembrane subunitHomologous Superfamily
C, G
IPR000701Succinate dehydrogenase/fumarate reductase type B, transmembrane subunitFamily
C, G
IPR014314Succinate dehydrogenase, cytochrome b556 subunitFamily
D, H
IPR034804Fumarate reductase/succinate dehydrogenase, transmembrane subunitHomologous Superfamily
D, H
IPR007992Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybSFamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

ChainsExternal LinkComment
A, B, C, D, E
MemProtMDAnnotated as membrane protein by MemProtMD