4YYM

Crystal structure of TAF1 BD2 Bromodomain bound to a butyryllysine peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bromodomain	8037197	3001843	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bromodomain	8037197	3001843	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bromodomain	e4yymA1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
B	Bromodomain	e4yymB1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
B	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00439	Bromodomain (Bromodomain)	Bromodomain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transcription initiation factor TFIID subunit 1	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity ubiquitin-protein transferase activity molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity ubiquitin-protein transferase activity molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein kinase activity phosphotransferase activity, alcohol group as acceptor transcription factor binding protein binding TBP-class protein binding general transcription initiation factor binding general transcription initiation factor activity RNA polymerase I general transcription initiation factor activity RNA polymerase II general transcription initiation factor activity double-stranded DNA binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding p53 binding modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding N-acetyltransferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups N-acyltransferase activity protein heterodimerization activity protein dimerization activity basal transcription machinery binding basal RNA polymerase II transcription machinery binding RNA polymerase II general transcription initiation factor binding protein serine kinase activity protein serine/threonine kinase activity nuclear receptor binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular biosynthetic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular biosynthetic process transcription preinitiation complex assembly RNA metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process cellular component assembly transcription by RNA polymerase II protein-containing complex assembly cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter protein-containing complex organization cellular metabolic process protein-DNA complex assembly primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process biosynthetic process RNA polymerase II preinitiation complex assembly metabolic process macromolecule metabolic process catabolic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process negative regulation of biological process regulation of ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of primary metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process regulation of catabolic process regulation of macromolecule metabolic process protein catabolic process modification-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process positive regulation of proteasomal protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process positive regulation of macromolecule metabolic process proteasomal protein catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein catabolic process protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation regulation of cell cycle phase transition regulation of cellular process regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of post-translational protein modification regulation of protein modification process regulation of protein autoubiquitination regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process regulation of protein modification by small protein conjugation or removal negative regulation of protein ubiquitination negative regulation of protein autoubiquitination negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification protein autoubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal protein autophosphorylation protein polyubiquitination mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process peptidyl-serine modification peptidyl-serine phosphorylation cellular response to nitrogen compound cellular response to ATP response to organophosphorus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to organic cyclic compound negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of protein binding positive regulation of molecular function regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding transcription initiation at RNA polymerase I promoter transcription by RNA polymerase I developmental process multicellular organismal process head development animal organ development brain development nervous system development multicellular organism development central nervous system development midbrain development anatomical structure development system development regulation of DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation positive regulation of transcription initiation by RNA polymerase II regulation of transcription initiation by RNA polymerase II regulation of signal transduction cell communication signal transduction positive regulation of signaling receptor activity regulation of response to stimulus regulation of DNA-binding transcription factor activity positive regulation of androgen receptor activity positive regulation of DNA-binding transcription factor activity signaling regulation of signaling receptor activity regulation of signaling regulation of cell communication response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV signal transduction by p53 class mediator intracellular signal transduction regulation of intracellular signal transduction regulation of signal transduction by p53 class mediator negative regulation of gene expression	protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle RNA polymerase II, holoenzyme intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle nucleoplasm catalytic complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex transcription factor TFIID complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle histone methyltransferase complex MLL1/2 complex MLL1 complex methyltransferase complex
C [auth Z]	Histone H4	DNA binding binding organic cyclic compound binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity RNA binding structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization organelle organization protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization organelle organization telomere organization chromosome organization protein localization protein localization to chromatin cellular localization protein localization to chromosome, centromeric region localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to CENP-A containing chromatin multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process regulation of megakaryocyte differentiation negative regulation of biological process megakaryocyte differentiation cell development regulation of cell differentiation regulation of cell development multicellular organism development negative regulation of megakaryocyte differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation regulation of immune system process regulation of multicellular organismal process developmental process regulation of biological process regulation of multicellular organismal development hemopoiesis negative regulation of developmental process regulation of myeloid cell differentiation biological regulation negative regulation of myeloid cell differentiation myeloid cell differentiation immune system process regulation of hemopoiesis	membrane cellular anatomical entity extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure CENP-A containing chromatin membrane cellular anatomical entity extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle protein-containing complex intracellular anatomical structure CENP-A containing chromatin protein-DNA complex nucleosome chromosome chromatin chromosomal region intracellular organelle chromosome, centromeric core domain CENP-A containing nucleosome intracellular non-membrane-bounded organelle chromosome, centromeric region non-membrane-bounded organelle chromosome, telomeric region nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018359	Bromodomain, conserved site	Conserved Site
A, B	IPR009067	TAFII-230 TBP-binding	Domain
A, B	IPR022591	Transcription initiation factor TFIID subunit 1, histone acetyltransferase domain	Domain
A, B	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A, B	IPR040240	Transcription initiation factor TFIID subunit 1	Family
A, B	IPR001487	Bromodomain	Domain
A, B	IPR041670	Zinc knuckle	Domain
A, B	IPR011177	Transcription initiation factor TFIID subunit 1, animal	Family
A, B	IPR036741	TAFII-230 TBP-binding domain superfamily	Homologous Superfamily
C [auth Z]	IPR009072	Histone-fold	Homologous Superfamily
C [auth Z]	IPR035425	CENP-T/Histone H4, histone fold	Domain
C [auth Z]	IPR001951	Histone H4	Family
C [auth Z]	IPR019809	Histone H4, conserved site	Conserved Site
C [auth Z]	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P21675	X-linked dystonia-parkinsonism dystonic disorder intellectual disability, X-linked, syndromic 33 intellectual disability Parkinson disease colorectal adenocarcinoma medulloblastoma metastatic melanoma rheumatoid arthritis generalized dystonia juvenile dermatomyositis osteosarcoma
C [auth Z]	Pharos: P62805	lung carcinoma Malignant neoplasm of breast non-small cell lung carcinoma Pick disease acute myeloid leukemia squamous cell lung carcinoma atypical teratoid rhabdoid tumor breast carcinoma ductal breast carcinoma in situ exocrine pancreatic carcinoma hepatocellular carcinoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis lung carcinoma Malignant neoplasm of breast non-small cell lung carcinoma Pick disease acute myeloid leukemia squamous cell lung carcinoma atypical teratoid rhabdoid tumor breast carcinoma ductal breast carcinoma in situ exocrine pancreatic carcinoma hepatocellular carcinoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm osteoarthritis pilocytic astrocytoma allergic rhinitis ulcerative colitis autism spectrum disorder cystic fibrosis endogenous depression glioblastoma hypertensive disorder lung cancer malignant mesothelioma multiple sclerosis osteosarcoma psoriasis astrocytic tumor breast cancer diabetes mellitus endometriosis gout invasive ductal breast carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C [auth Z]	BTK	Parent Component: LYS RESID: AA0532 PSI-MOD : N6-butanoyl-L-lysine MOD:01781

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.