Annotations: 4Z3W

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AFOR_C	e4z3wA2	A: alpha complex topology	X: Aldehyde ferredoxin oxidoreductase-C (From Topology)	H: Aldehyde ferredoxin oxidoreductase-C (From Topology)	T: Aldehyde ferredoxin oxidoreductase-C	F: AFOR_C	ECOD (1.6)
A	AFOR_N	e4z3wA1	A: a+b four layers	X: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	H: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	T: Aldehyde ferredoxin oxidoreductase, N-terminal domain	F: AFOR_N	ECOD (1.6)
B	AFOR_C	e4z3wB2	A: alpha complex topology	X: Aldehyde ferredoxin oxidoreductase-C (From Topology)	H: Aldehyde ferredoxin oxidoreductase-C (From Topology)	T: Aldehyde ferredoxin oxidoreductase-C	F: AFOR_C	ECOD (1.6)
B	AFOR_N	e4z3wB1	A: a+b four layers	X: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	H: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	T: Aldehyde ferredoxin oxidoreductase, N-terminal domain	F: AFOR_N	ECOD (1.6)
C	AFOR_C	e4z3wC2	A: alpha complex topology	X: Aldehyde ferredoxin oxidoreductase-C (From Topology)	H: Aldehyde ferredoxin oxidoreductase-C (From Topology)	T: Aldehyde ferredoxin oxidoreductase-C	F: AFOR_C	ECOD (1.6)
C	AFOR_N	e4z3wC1	A: a+b four layers	X: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	H: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	T: Aldehyde ferredoxin oxidoreductase, N-terminal domain	F: AFOR_N	ECOD (1.6)
D	AFOR_C	e4z3wD2	A: alpha complex topology	X: Aldehyde ferredoxin oxidoreductase-C (From Topology)	H: Aldehyde ferredoxin oxidoreductase-C (From Topology)	T: Aldehyde ferredoxin oxidoreductase-C	F: AFOR_C	ECOD (1.6)
D	AFOR_N	e4z3wD1	A: a+b four layers	X: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	H: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	T: Aldehyde ferredoxin oxidoreductase, N-terminal domain	F: AFOR_N	ECOD (1.6)
F	Fer4_11_1	e4z3wF1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_11_1	ECOD (1.6)
G	Fer4_11_1	e4z3wG1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_11_1	ECOD (1.6)
H	Fer4_11_1	e4z3wH1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_11_1	ECOD (1.6)
E	Fer4_11_1	e4z3wE1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_11_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.9.10	Alpha Beta	4-Layer Sandwich	Aldehyde Ferredoxin Oxidoreductase	A, domain 1	CATH (4.3.0)
A	1.10.569.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 2	CATH (4.3.0)
B	3.60.9.10	Alpha Beta	4-Layer Sandwich	Aldehyde Ferredoxin Oxidoreductase	A, domain 1	CATH (4.3.0)
B	1.10.569.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 2	CATH (4.3.0)
C	3.60.9.10	Alpha Beta	4-Layer Sandwich	Aldehyde Ferredoxin Oxidoreductase	A, domain 1	CATH (4.3.0)
C	1.10.569.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 2	CATH (4.3.0)
D	3.60.9.10	Alpha Beta	4-Layer Sandwich	Aldehyde Ferredoxin Oxidoreductase	A, domain 1	CATH (4.3.0)
D	1.10.569.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02730	Aldehyde ferredoxin oxidoreductase, N-terminal domain (AFOR_N)	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This domain interacts with the tungsten cofactor [1].	Domain
A, B, C, D	PF01314	Aldehyde ferredoxin oxidoreductase, domains 2 & 3 (AFOR_C)	Aldehyde ferredoxin oxidoreductase, domains 2 & 3	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains t ...	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains that bind the tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR [1].	Domain
E, F, G, H	PF12837	4Fe-4S binding domain (Fer4_6)	4Fe-4S binding domain	This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Benzoyl-CoA reductase, putative	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding electron transfer activity cation binding ion binding metal ion binding	-	-
E, F, G, H	Iron-sulfur cluster-binding oxidoreductase, putative benzoyl-CoA reductase electron transfer protein	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR013985	Aldehyde ferredoxin oxidoreductase, domain 3	Homologous Superfamily
A, B, C, D	IPR036503	Aldehyde ferredoxin oxidoreductase, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR001203	Aldehyde ferredoxin oxidoreductase, C-terminal	Domain
A, B, C, D	IPR013983	Aldehyde ferredoxin oxidoreductase, N-terminal	Domain
A, B, C, D	IPR013984	Aldehyde ferredoxin oxidoreductase, domain 2	Homologous Superfamily
A, B, C, D	IPR051919	Tungsten-dependent aldehyde:ferredoxin oxidoreductase	Family
A, B, C, D	IPR036021	Aldehyde ferredoxin oxidoreductase-like, C-terminal	Homologous Superfamily
E, F, G, H	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.