Annotations: 4ZC4

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DM15	e4zc4A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: DM15	ECOD (1.6)
B	DM15	e4zc4B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: DM15	ECOD (1.6)
C	DM15	e4zc4C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: DM15	ECOD (1.6)
D	DM15	e4zc4D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: DM15	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF21071	LARP1 HEAT repeat region (LARP1_HEAT)	LARP1 HEAT repeat region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	La-related protein 1	mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding RNA cap binding eukaryotic initiation factor 4E binding protein binding translation initiation factor binding translation regulator activity translation activator activity translation regulator activity, nucleic acid binding RNA 7-methylguanosine cap binding mRNA 3'-UTR binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding RNA cap binding eukaryotic initiation factor 4E binding protein binding translation initiation factor binding translation regulator activity translation activator activity translation regulator activity, nucleic acid binding RNA 7-methylguanosine cap binding cell adhesion molecule binding cadherin binding mRNA 5'-UTR binding ribonucleoprotein complex binding protein-containing complex binding ribosomal small subunit binding ribosome binding	biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular response to stimulus cellular response to nitrogen compound response to ketone response to stimulus biosynthetic process translational initiation metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process translation gene expression macromolecule biosynthetic process cellular response to stimulus cellular response to nitrogen compound response to ketone response to stimulus response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to ether cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to ether response to chemical response to rapamycin cellular response to rapamycin cellular response to ketone response to organic cyclic compound regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process response to nutrient levels response to stress response to amino acid starvation response to starvation cell population proliferation TOR signaling signaling intracellular signal transduction cell communication signal transduction TORC1 signaling positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process nucleobase-containing compound catabolic process nucleic acid catabolic process negative regulation of RNA metabolic process catabolic process positive regulation of biological process RNA metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process regulation of mRNA catabolic process positive regulation of biosynthetic process positive regulation of cellular process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of catabolic process mRNA metabolic process nucleic acid metabolic process regulation of mRNA stability RNA stabilization positive regulation of gene expression regulation of RNA stability regulation of mRNA metabolic process positive regulation of protein metabolic process positive regulation of translation positive regulation of autophagy macroautophagy autophagy regulation of autophagy positive regulation of catabolic process regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of viral genome replication positive regulation of viral process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication regulation of translational initiation negative regulation of translational initiation positive regulation of translational initiation	intracellular anatomical structure cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule intracellular organelle cellular anatomical structure organelle membraneless organelle cytoplasm supramolecular complex cytoplasmic stress granule membrane cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR006630	La-type HTH domain	Domain
A, B, C, D	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR006607	LARP1-like, DM15 repeat	Repeat
A, B, C, D	IPR045180	La domain containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q6PKG0	astrocytic tumor lung cancer ovarian cancer dermatomyositis malignant glioma psoriasis large cell medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.