4ZFJ

Ergothioneine-biosynthetic Ntn hydrolase EgtC, apo form

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GATase_4	e4zfjA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
B	GATase_4	e4zfjB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
D	GATase_4	e4zfjD1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
F	GATase_4	e4zfjF1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
G	GATase_4	e4zfjG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
H	GATase_4	e4zfjH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
K	GATase_4	e4zfjK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
C	GATase_4	e4zfjC1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
E	GATase_4	e4zfjE1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
I	GATase_4	e4zfjI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
J	GATase_4	e4zfjJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)
L	GATase_4	e4zfjL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Class II glutamine amidotransferases	F: GATase_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
B	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
D	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
F	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
G	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
H	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
K	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
C	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
E	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
I	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
J	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)
L	3.60.20.10	Alpha Beta	4-Layer Sandwich	Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1	Aminohydrolase, N-terminal nucleophile (Ntn) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF13230	Glutamine amidotransferases class-II (GATase_4)	Glutamine amidotransferases class-II	This family captures members that are not found in Pfam:PF00310.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Amidohydrolase EgtC	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide amino-acid betaine biosynthetic process oxoacid metabolic process sulfur amino acid metabolic process modified amino acid biosynthetic process organic acid metabolic process organic acid biosynthetic process ergothioneine metabolic process carboxylic acid biosynthetic process modified histidine biosynthetic process sulfur compound metabolic process small molecule metabolic process small molecule biosynthetic process carboxylic acid metabolic process ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide amino-acid betaine biosynthetic process oxoacid metabolic process sulfur amino acid metabolic process modified amino acid biosynthetic process organic acid metabolic process organic acid biosynthetic process ergothioneine metabolic process carboxylic acid biosynthetic process modified histidine biosynthetic process sulfur compound metabolic process small molecule metabolic process small molecule biosynthetic process carboxylic acid metabolic process modified amino acid metabolic process amino-acid betaine metabolic process sulfur compound biosynthetic process biosynthetic process ergothioneine biosynthetic process metabolic process cellular process modified histidine metabolic process sulfur amino acid biosynthetic process glutamine metabolic process amino acid metabolic process primary metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR032889	Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase, Actinobacteria	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR052373	Gamma-glutamyl amide hydrolase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR017932	Glutamine amidotransferase type 2 domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR026869	Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase EgtC-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR017808	Ergothioneine biosynthesis protein EgtC	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.