Annotations: 4ZVC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CZB_like	e4zvcA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Regulatory CZB domain of diguanylate cyclase YdeH (From Topology)	T: Regulatory CZB domain of diguanylate cyclase YdeH	F: CZB_like	ECOD (1.6)
B	CZB_like	e4zvcB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Regulatory CZB domain of diguanylate cyclase YdeH (From Topology)	T: Regulatory CZB domain of diguanylate cyclase YdeH	F: CZB_like	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21118	DosC CZB-like middle domain (DosC_2nd)	DosC CZB-like middle domain	This entry represents the middle (Mid) domain of DosC proteins an oxygen-regulated diguanylate cyclase [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Diguanylate cyclase DosC	oxygen binding binding small molecule binding transferase activity nucleotidyltransferase activity catalytic activity diguanylate cyclase activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity organic cyclic compound binding tetrapyrrole binding oxygen binding binding small molecule binding transferase activity nucleotidyltransferase activity catalytic activity diguanylate cyclase activity transferase activity, transferring phosphorus-containing groups identical protein binding protein binding protein homodimerization activity protein dimerization activity organic cyclic compound binding tetrapyrrole binding heme binding carbon monoxide binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding cation binding metal ion binding	response to stimulus response to stress regulation of bacterial-type flagellum-dependent cell motility negative regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process biological regulation negative regulation of biological process archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility regulation of locomotion negative regulation of cellular process negative regulation of cell motility response to stimulus response to stress regulation of bacterial-type flagellum-dependent cell motility negative regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process biological regulation negative regulation of biological process archaeal or bacterial-type flagellum-dependent cell motility cilium or flagellum-dependent cell motility regulation of locomotion negative regulation of cellular process negative regulation of cell motility cellular process bacterial-type flagellum-dependent cell motility cell motility negative regulation of bacterial-type flagellum-dependent cell motility locomotion response to oxygen levels response to abiotic stimulus cell adhesion involved in biofilm formation cell aggregation biofilm formation biological process involved in intraspecies interaction between organisms cell-substrate adhesion single-species biofilm formation aggregation of unicellular organisms submerged biofilm formation cell adhesion involved in single-species biofilm formation cell adhesion single-species submerged biofilm formation	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050469	Bacterial Diguanylate Cyclase	Family
A, B	IPR000160	GGDEF domain	Domain
A, B	IPR009050	Globin-like superfamily	Homologous Superfamily
A, B	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
A, B	IPR012292	Globin/Protoglobin	Homologous Superfamily
A, B	IPR044398	Globin-sensor domain	Domain
A, B	IPR048442	DosC, CZB-like middle domain	Domain
A, B	IPR039435	Diguanylate cyclase DosC, globin sensor domain	Domain
A, B	IPR029787	Nucleotide cyclase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.