4AW6

Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 (FACE1)


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyMetalloproteases (zincins), catalytic domain 8049050 3001975 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMetalloproteases (zincins), catalytic domain 8049050 3001975 SCOP2B (2022-06-29)
C [auth D]SCOP2B SuperfamilyMetalloproteases (zincins), catalytic domain 8049050 3001975 SCOP2B (2022-06-29)
D [auth E]SCOP2B SuperfamilyMetalloproteases (zincins), catalytic domain 8049050 3001975 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_M48e4aw6A1 A: mixed a+b and a/bX: Zincin-likeH: Metalloproteases (zincins) catalytic domain (From Topology)T: Metalloproteases (zincins) catalytic domainF: Peptidase_M48ECOD (1.6)
BPeptidase_M48e4aw6B1 A: mixed a+b and a/bX: Zincin-likeH: Metalloproteases (zincins) catalytic domain (From Topology)T: Metalloproteases (zincins) catalytic domainF: Peptidase_M48ECOD (1.6)
C [auth D]Peptidase_M48e4aw6D1 A: mixed a+b and a/bX: Zincin-likeH: Metalloproteases (zincins) catalytic domain (From Topology)T: Metalloproteases (zincins) catalytic domainF: Peptidase_M48ECOD (1.6)
D [auth E]Peptidase_M48e4aw6E1 A: mixed a+b and a/bX: Zincin-likeH: Metalloproteases (zincins) catalytic domain (From Topology)T: Metalloproteases (zincins) catalytic domainF: Peptidase_M48ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
B,
C [auth D],
D [auth E]
PF16491CAAX prenyl protease N-terminal, five membrane helices (Peptidase_M48_N)CAAX prenyl protease N-terminal, five membrane helicesThe five N-terminal five transmembrane alpha-helices of peptidase_M48 family proteins including the CAAX prenyl proteases reside completely within the membrane of the endoplasmic reticulum.Domain
A,
B,
C [auth D],
D [auth E]
PF01435Peptidase family M48 (Peptidase_M48)Peptidase family M48Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent gluta ...Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit [1,2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
B,
C [auth D],
D [auth E]
CAAX PRENYL PROTEASE 1 HOMOLOG

Membrane Protein Annotation: OPM OPM Database Homepage

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage