Annotations: 4BXS

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trypsin	e4bxsA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin	ECOD (1.6)
A	FXa_inhibition	e4bxsA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: FXa_inhibition	ECOD (1.6)
B [auth V]	F5_F8_type_C	e4bxsV9	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C	ECOD (1.6)
B [auth V]	Cu-oxidase_2_1	e4bxsV7	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: Cu-oxidase_2_1	ECOD (1.6)
B [auth V]	Cu-oxidase_3_2	e4bxsV2	A: beta sandwiches	X: Cupredoxin-like	H: Cupredoxin-related (From Topology)	T: Cupredoxin-related	F: Cu-oxidase_3_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)
B [auth V]	2.60.40.420	Mainly Beta	Sandwich	Immunoglobulin-like	Cupredoxins - blue copper proteins	CATH (4.3.0)
B [auth V]	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14670	Coagulation Factor Xa inhibitory site (FXa_inhibition)	Coagulation Factor Xa inhibitory site	This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].	Domain
B [auth V]	PF00754	F5/8 type C domain (F5_F8_type_C)	F5/8 type C domain	This domain is also known as the discoidin (DS) domain family [1].	Domain
B [auth V]	PF07732	Multicopper oxidase (Cu-oxidase_3)	Multicopper oxidase	This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FACTOR X-LIKE PROTEASE	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity toxin activity	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding envenomation resulting in modulation of process in another organism envenomation resulting in modulation of blood coagulation in another organism biological process involved in interspecies interaction between organisms multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding envenomation resulting in modulation of process in another organism envenomation resulting in modulation of blood coagulation in another organism biological process involved in interspecies interaction between organisms envenomation resulting in impairment of hemostasis in another organism envenomation resulting in positive regulation of blood coagulation in another organism modulation of process of another organism induction of blood coagulation in another organism perturbation of blood coagulation in another organism proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	protein-containing complex cellular anatomical structure extracellular region
B [auth V]	VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT	enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity toxin activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding	envenomation resulting in modulation of process in another organism envenomation resulting in modulation of blood coagulation in another organism biological process involved in interspecies interaction between organisms envenomation resulting in impairment of hemostasis in another organism envenomation resulting in positive regulation of blood coagulation in another organism modulation of process of another organism induction of blood coagulation in another organism perturbation of blood coagulation in another organism	cellular anatomical structure extracellular region protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000294	Gamma-carboxyglutamic acid-rich (GLA) domain	Domain
A	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
A	IPR000742	EGF-like domain	Domain
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A	IPR050442	Peptidase S1 family, coagulation factors	Family
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR017857	Coagulation factor-like, Gla domain superfamily	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR035972	Gamma-carboxyglutamic acid-rich (GLA) domain superfamily	Homologous Superfamily
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM
A	IPR012224	Peptidase S1A, coagulation factor VII/IX/X/C/Z	Family
B [auth V]	IPR033138	Multicopper oxidases, conserved site	Conserved Site
B [auth V]	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
B [auth V]	IPR011707	Multicopper oxidase-like, N-terminal	Domain
B [auth V]	IPR024715	Coagulation factor 5/8-like	Family
B [auth V]	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain
B [auth V]	IPR008972	Cupredoxin	Homologous Superfamily
B [auth V]	IPR050633	Neuropilin/Multicopper Oxidase/Coagulation Factor	Family