4DIP

Crystal structure of human Peptidyl-prolyl cis-trans isomerase FKBP14

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4dipa1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4dipa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4dipb1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4dipb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4dipc_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4dipd_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d4dipe_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d4dipf_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d4dipg_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d4diph_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d4dipi1	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d4dipi2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d4dipj_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FKBP_C	e4dipA1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
B	FKBP_C	e4dipB1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
C	FKBP_C	e4dipC1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
D	FKBP_C	e4dipD1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
E	FKBP_C	e4dipE1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
F	FKBP_C	e4dipF1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
G	FKBP_C	e4dipG1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
H	FKBP_C	e4dipH1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
I	FKBP_C	e4dipI1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)
J	FKBP_C	e4dipJ1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
B	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
C	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
D	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
E	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
F	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
G	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
H	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
I	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)
J	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Peptidyl-prolyl cis-trans isomerase FKBP14	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity	-	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR002048	EF-hand domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR052273	Peptidyl-prolyl cis-trans isomerase FKBP	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Pharos: Q9NWM8	Ehlers-Danlos syndrome Ehlers-Danlos syndrome, kyphoscoliotic and deafness type adrenal cortex carcinoma Congenital myopathy (disorder) glioblastoma lung cancer non-small cell lung carcinoma Pick disease arthrogryposis intellectual disability malignant mesothelioma osteosarcoma pituitary cancer large cell medulloblastoma medulloblastoma Ehlers-Danlos syndrome Ehlers-Danlos syndrome, kyphoscoliotic and deafness type adrenal cortex carcinoma Congenital myopathy (disorder) glioblastoma lung cancer non-small cell lung carcinoma Pick disease arthrogryposis intellectual disability malignant mesothelioma osteosarcoma pituitary cancer large cell medulloblastoma medulloblastoma ovarian cancer psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.