4DRM

EVALUATION OF SYNTHETIC FK506 ANALOGS AS LIGANDS FOR FKBP51 AND FKBP52: COMPLEX OF FKBP51 WITH {3-[(1R)-3-(3,4-dimethoxyphenyl)-1-({[(2S)-1-{[(1S,2R)-2-ethyl-1-hydroxycyclohexyl](oxo)acetyl}piperidin-2-yl]carbonyl}oxy)propyl]phenoxy}acetic acid


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4drma1 Alpha and beta proteins (a+b) FKBP-like FKBP-like FKBP immunophilin/proline isomerase automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad4drma2 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRotamase-like 8042824 3000622 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFKBP_Ce4drmA1 A: a+b two layersX: FKBP-likeH: FKBP-likeT: FKBP-likeF: FKBP_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.50.40 Alpha Beta Roll Chitinase A domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00254FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)FKBP-type peptidyl-prolyl cis-trans isomerase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Peptidyl-prolyl cis-trans isomerase FKBP5

Pharos: Disease Associations Pharos Homepage Annotation