4DRP

Evaluation of Synthetic FK506 Analogs as Ligands for the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1R,2S)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid from cocrystallization


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4drpa1 Alpha and beta proteins (a+b) FKBP-like FKBP-like FKBP immunophilin/proline isomerase automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad4drpa2 Artifacts Tags Tags Tags N-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRotamase-like 8042824 3000622 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFKBP_Ce4drpA1 A: a+b two layersX: FKBP-likeH: FKBP-likeT: FKBP-likeF: FKBP_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.10.50.40 Alpha Beta Roll Chitinase A domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00254FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)FKBP-type peptidyl-prolyl cis-trans isomerase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Peptidyl-prolyl cis-trans isomerase FKBP5

Pharos: Disease Associations Pharos Homepage Annotation