4FIO

Crystal Structure of Methenyltetrahydromethanopterin Cyclohydrolase from Methanobrevibacter ruminantium

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4fioa_	Alpha and beta proteins (a+b)	Methenyltetrahydromethanopterin cyclohydrolase	Methenyltetrahydromethanopterin cyclohydrolase	automated matches	automated matches	(Methanobrevibacter ruminantium M1 ) [TaxId: 634498 ],	SCOPe (2.08)
B	d4fiob_	Alpha and beta proteins (a+b)	Methenyltetrahydromethanopterin cyclohydrolase	Methenyltetrahydromethanopterin cyclohydrolase	automated matches	automated matches	(Methanobrevibacter ruminantium M1 ) [TaxId: 634498 ],	SCOPe (2.08)
C	d4fioc_	Alpha and beta proteins (a+b)	Methenyltetrahydromethanopterin cyclohydrolase	Methenyltetrahydromethanopterin cyclohydrolase	automated matches	automated matches	(Methanobrevibacter ruminantium M1 ) [TaxId: 634498 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Methenyltetrahydromethanopterin cyclohydrolase	8083721	4002190	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Methenyltetrahydromethanopterin cyclohydrolase	8083722	3000946	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Methenyltetrahydromethanopterin cyclohydrolase	8083722	3000946	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Methenyltetrahydromethanopterin cyclohydrolase	8083722	3000946	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MCH	e4fioA1	A: a+b complex topology	X: Methenyltetrahydromethanopterin cyclohydrolase (From Topology)	H: Methenyltetrahydromethanopterin cyclohydrolase (From Topology)	T: Methenyltetrahydromethanopterin cyclohydrolase	F: MCH	ECOD (1.6)
B	MCH	e4fioB1	A: a+b complex topology	X: Methenyltetrahydromethanopterin cyclohydrolase (From Topology)	H: Methenyltetrahydromethanopterin cyclohydrolase (From Topology)	T: Methenyltetrahydromethanopterin cyclohydrolase	F: MCH	ECOD (1.6)
C	MCH	e4fioC1	A: a+b complex topology	X: Methenyltetrahydromethanopterin cyclohydrolase (From Topology)	H: Methenyltetrahydromethanopterin cyclohydrolase (From Topology)	T: Methenyltetrahydromethanopterin cyclohydrolase	F: MCH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.340.11	Alpha Beta	Roll	Methenyltetrahydromethanopterin Cyclohydrolase	Chain A, domain 1	CATH (4.3.0)
A	3.30.1030.10	Alpha Beta	2-Layer Sandwich	Methenyltetrahydromethanopterin Cyclohydrolase	Chain A, domain 2	CATH (4.3.0)
B	3.10.340.11	Alpha Beta	Roll	Methenyltetrahydromethanopterin Cyclohydrolase	Chain A, domain 1	CATH (4.3.0)
B	3.30.1030.10	Alpha Beta	2-Layer Sandwich	Methenyltetrahydromethanopterin Cyclohydrolase	Chain A, domain 2	CATH (4.3.0)
C	3.10.340.11	Alpha Beta	Roll	Methenyltetrahydromethanopterin Cyclohydrolase	Chain A, domain 1	CATH (4.3.0)
C	3.30.1030.10	Alpha Beta	2-Layer Sandwich	Methenyltetrahydromethanopterin Cyclohydrolase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF02289	Cyclohydrolase (MCH) (MCH)	Cyclohydrolase (MCH)	Methenyl tetrahydromethanopterin cyclohydrolase EC:3.5.4.27 is involved in methanogenesis in bacteria and archaea, producing methane from carbon monoxide or carbon dioxide.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Methenyltetrahydromethanopterin cyclohydrolase	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines methenyltetrahydromethanopterin cyclohydrolase activity cyclohydrolase activity hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	cellular respiration energy derivation by oxidation of organic compounds cellular biosynthetic process cellular metabolic process alkane biosynthetic process methane metabolic process generation of precursor metabolites and energy hydrocarbon metabolic process biosynthetic process energy derivation by oxidation of reduced inorganic compounds cellular alkane metabolic process methanogenesis metabolic process cellular process cellular respiration energy derivation by oxidation of organic compounds cellular biosynthetic process cellular metabolic process alkane biosynthetic process methane metabolic process generation of precursor metabolites and energy hydrocarbon metabolic process biosynthetic process energy derivation by oxidation of reduced inorganic compounds cellular alkane metabolic process methanogenesis metabolic process cellular process hydrocarbon biosynthetic process methanogenesis, from carbon dioxide anaerobic respiration small molecule metabolic process one-carbon metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR003209	Methenyltetrahydromethanopterin cyclohydrolase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.