Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth D]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)
B [auth C]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)
C [auth A]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8036943 3001442 SCOP2B (2022-06-29)
D [auth B]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8036943 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth D]Hormone_recepe4j5xD1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
B [auth C]Hormone_recepe4j5xC1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
C [auth A]Hormone_recep_1e4j5xA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)
D [auth B]Hormone_recep_1e4j5xB1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth D],
B [auth C]
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain
C [auth A],
D [auth B]
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth D],
B [auth C]
Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 1
C [auth A],
D [auth B]
Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth D],
B [auth C]
IPR010011Nuclear receptor coactivator, DUF1518Domain
A [auth D],
B [auth C]
IPR028819Nuclear receptor coactivator 1, basic helix-loop-helixDomain
A [auth D],
B [auth C]
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
A [auth D],
B [auth C]
IPR017426Nuclear receptor coactivatorFamily
A [auth D],
B [auth C]
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
A [auth D],
B [auth C]
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
A [auth D],
B [auth C]
IPR035965PAS domain superfamilyHomologous Superfamily
A [auth D],
B [auth C]
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily
A [auth D],
B [auth C]
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
A [auth D],
B [auth C]
IPR013767PAS foldDomain
A [auth D],
B [auth C]
IPR000014PAS domainDomain
A [auth D],
B [auth C]
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain
A [auth D],
B [auth C]
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
A [auth D],
B [auth C]
IPR021780Nuclear/hormone receptor activator site AF-1Domain
A [auth D],
B [auth C]
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
A [auth D],
B [auth C]
IPR000003Retinoid X receptor/HNF4Family
A [auth D],
B [auth C]
IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
A [auth D],
B [auth C]
IPR001723Nuclear hormone receptorFamily
A [auth D],
B [auth C]
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
A [auth D],
B [auth C]
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
C [auth A],
D [auth B]
IPR010011Nuclear receptor coactivator, DUF1518Domain
C [auth A],
D [auth B]
IPR028819Nuclear receptor coactivator 1, basic helix-loop-helixDomain
C [auth A],
D [auth B]
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
C [auth A],
D [auth B]
IPR017426Nuclear receptor coactivatorFamily
C [auth A],
D [auth B]
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
C [auth A],
D [auth B]
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
C [auth A],
D [auth B]
IPR035965PAS domain superfamilyHomologous Superfamily
C [auth A],
D [auth B]
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily
C [auth A],
D [auth B]
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
C [auth A],
D [auth B]
IPR013767PAS foldDomain
C [auth A],
D [auth B]
IPR000014PAS domainDomain
C [auth A],
D [auth B]
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain
C [auth A],
D [auth B]
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
C [auth A],
D [auth B]
IPR050234Nuclear hormone receptor family NR1 subfamilyFamily
C [auth A],
D [auth B]
IPR001723Nuclear hormone receptorFamily
C [auth A],
D [auth B]
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
C [auth A],
D [auth B]
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
C [auth A],
D [auth B]
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth D],
B [auth C]
PharosP19793
C [auth A],
D [auth B]
PharosO75469