Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth B]SCOP2B SuperfamilyFKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 8036936 3001600 SCOP2B (2022-06-29)
C [auth A]SCOP2B SuperfamilyFKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) 8036936 3001600 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]FRB_dome4jsxB1 A: alpha bundlesX: Four-helical up-and-down bundleH: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) (From Topology)T: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)F: FRB_domECOD (1.6)
A [auth B]FATe4jsxB2 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: FATECOD (1.6)
A [auth B]PI3_PI4_kinasee4jsxB3 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: PI3_PI4_kinaseECOD (1.6)
C [auth A]FRB_dome4jsxA1 A: alpha bundlesX: Four-helical up-and-down bundleH: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) (From Topology)T: FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)F: FRB_domECOD (1.6)
C [auth A]FATe4jsxA2 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: FATECOD (1.6)
C [auth A]PI3_PI4_kinasee4jsxA3 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: PI3_PI4_kinaseECOD (1.6)
D [auth C]ANAPC4_WD40_9e4jsxC1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_9ECOD (1.6)
B [auth D]ANAPC4_WD40_9e4jsxD1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_9ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
D [auth C]2.130.10.10 Mainly Beta 7 Propeller Methylamine Dehydrogenase Chain HCATH (4.3.0)
B [auth D]2.130.10.10 Mainly Beta 7 Propeller Methylamine Dehydrogenase Chain HCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
C [auth A]
PF02260FATC domain (FATC)FATC domain- Family
A [auth B],
C [auth A]
PF08771FKBP12-rapamycin binding domain (FRB_dom)FKBP12-rapamycin binding domainThe macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapa ...The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the TOR proteins. This entry represents the FRB domain [1, 2].
Domain
A [auth B],
C [auth A]
PF00454Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)Phosphatidylinositol 3- and 4-kinase- Family
A [auth B],
C [auth A]
PF02259FAT domain (FAT)FAT domain- Repeat
B [auth D],
D [auth C]
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
C [auth A]
Serine/threonine-protein kinase mTOR
B [auth D],
D [auth C]
Target of rapamycin complex subunit LST8

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
C [auth A]
IPR016024Armadillo-type foldHomologous Superfamily
A [auth B],
C [auth A]
IPR009076FKBP12-rapamycin binding domainDomain
A [auth B],
C [auth A]
IPR011990Tetratricopeptide-like helical domain superfamilyHomologous Superfamily
A [auth B],
C [auth A]
IPR018936Phosphatidylinositol 3/4-kinase, conserved siteConserved Site
A [auth B],
C [auth A]
IPR036940Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyHomologous Superfamily
A [auth B],
C [auth A]
IPR014009PIK-related kinaseDomain
A [auth B],
C [auth A]
IPR026683Serine/threonine-protein kinase TOR, catalytic domainDomain
A [auth B],
C [auth A]
IPR003151PIK-related kinase, FATDomain
A [auth B],
C [auth A]
IPR036738FKBP12-rapamycin binding domain superfamilyHomologous Superfamily
A [auth B],
C [auth A]
IPR003152FATC domainDomain
A [auth B],
C [auth A]
IPR024585Serine/threonine-protein kinase mTOR domainDomain
A [auth B],
C [auth A]
IPR011989Armadillo-like helicalHomologous Superfamily
A [auth B],
C [auth A]
IPR000403Phosphatidylinositol 3-/4-kinase, catalytic domainDomain
A [auth B],
C [auth A]
IPR050517DNA Damage Response and Repair KinaseFamily
A [auth B],
C [auth A]
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
B [auth D],
D [auth C]
IPR019775WD40 repeat, conserved siteConserved Site
B [auth D],
D [auth C]
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilyHomologous Superfamily
B [auth D],
D [auth C]
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
B [auth D],
D [auth C]
IPR001680WD40 repeatRepeat
B [auth D],
D [auth C]
IPR037588Target of rapamycin complex subunit LST8Family
B [auth D],
D [auth C]
IPR020472G-protein beta WD-40 repeatRepeat

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth B],
C [auth A]
PharosP42345
B [auth D],
D [auth C]
PharosQ9BVC4