Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNAD(P)-linked oxidoreductase 8040991 3000288 SCOP2B (2022-06-29)
C [auth G]SCOP2B SuperfamilyNAD(P)-linked oxidoreductase 8040991 3000288 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPOZ domain 8035031 3000894 SCOP2B (2022-06-29)
D [auth H]SCOP2B SuperfamilyPOZ domain 8035031 3000894 SCOP2B (2022-06-29)
E [auth Y]SCOP2B SuperfamilyScorpion toxin-like 8038204 3000309 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAldo_ket_rede4jtcA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Aldo_ket_redECOD (1.6)
C [auth G]Aldo_ket_rede4jtcG1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Aldo_ket_redECOD (1.6)
BIon_transe4jtcB2 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: Ion_transECOD (1.6)
BBTB_2e4jtcB3 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTB_2ECOD (1.6)
D [auth H]Ion_transe4jtcH1 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: Ion_transECOD (1.6)
D [auth H]BTB_2e4jtcH2 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTB_2ECOD (1.6)
E [auth Y]Toxin_2e4jtcY1 A: few secondary structure elementsX: omega toxin-likeH: omega toxin-relatedT: Scorpion toxin-likeF: Toxin_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
C [auth G]
PF00248Aldo/keto reductase family (Aldo_ket_red)Aldo/keto reductase familyThis family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].Domain
B,
D [auth H]
PF02214BTB/POZ domain (BTB_2)BTB/POZ domainIn voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homo ...In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].
Domain
B,
D [auth H]
PF07885Ion channel (Ion_trans_2)Ion channel- Family
B,
D [auth H]
PF00520Ion transport protein (Ion_trans)Ion transport protein- Family
E [auth Y]PF00451Scorpion short toxin, BmKK2 (Toxin_2)Scorpion short toxin, BmKK2Members of this family, which are found in various scorpion toxins, confer potassium channel blocking activity [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
C [auth G]
Voltage-gated potassium channel subunit beta-2
B,
D [auth H]
Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1
E [auth Y]Potassium channel toxin alpha-KTx 1.1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
C [auth G]
IPR005399Potassium channel, voltage-dependent, beta subunit, KCNAB-relatedFamily
A,
C [auth G]
IPR036812NADP-dependent oxidoreductase domain superfamilyHomologous Superfamily
A,
C [auth G]
IPR005401Potassium channel, voltage-dependent, beta subunit, KCNAB2Family
A,
C [auth G]
IPR023210NADP-dependent oxidoreductase domainDomain
A,
C [auth G]
IPR005983Potassium channel, voltage-dependent, beta subunit, KCNABFamily
B,
D [auth H]
IPR003973Potassium channel, voltage dependent, Kv2Family
B,
D [auth H]
IPR003968Potassium channel, voltage dependent, KvFamily
B,
D [auth H]
IPR004350Potassium channel, voltage dependent, Kv2.1Family
B,
D [auth H]
IPR003131Potassium channel tetramerisation-type BTB domainDomain
B,
D [auth H]
IPR011333SKP1/BTB/POZ domain superfamilyHomologous Superfamily
B,
D [auth H]
IPR000210BTB/POZ domainDomain
B,
D [auth H]
IPR005821Ion transport domainDomain
B,
D [auth H]
IPR027359Voltage-dependent channel domain superfamilyHomologous Superfamily
B,
D [auth H]
IPR003972Potassium channel, voltage dependent, Kv1Family
B,
D [auth H]
IPR000210BTB/POZ domainDomain
B,
D [auth H]
IPR003968Potassium channel, voltage dependent, KvFamily
B,
D [auth H]
IPR005821Ion transport domainDomain
B,
D [auth H]
IPR003131Potassium channel tetramerisation-type BTB domainDomain
B,
D [auth H]
IPR004049Potassium channel, voltage dependent, Kv1.2Family
B,
D [auth H]
IPR011333SKP1/BTB/POZ domain superfamilyHomologous Superfamily
B,
D [auth H]
IPR027359Voltage-dependent channel domain superfamilyHomologous Superfamily
E [auth Y]IPR036574Knottin, scorpion toxin-like superfamilyHomologous Superfamily
E [auth Y]IPR001947Scorpion short chain toxin, potassium channel inhibitorFamily

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
E [auth Y]PCA Parent Component: GLN

RESIDAA0031

PSI-MOD :  2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420