4UEC

Complex of D. melanogaster eIF4E with eIF4G and cap analog

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4ueca1	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d4ueca2	Artifacts	Tags	Tags	Tags	N-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C	d4uecc1	Alpha and beta proteins (a+b)	eIF4e-like	eIF4e-like	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C	d4uecc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	eIF4e-like	8072936	3001871	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	eIF4e-like	8072936	3001871	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IF4E	e4uecA1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)
C	IF4E	e4uecC1	A: a+b two layers	X: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	H: Translation initiation factor eIF4e and phosphothreonine lyase (From Topology)	T: Translation initiation factor eIF4e and phosphothreonine lyase	F: IF4E	ECOD (1.6)
B	eIF_4G1_like	e4uecB1	A: alpha arrays	X: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology)	H: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain (From Topology)	T: Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain	F: eIF_4G1_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)
C	3.30.760.10	Alpha Beta	2-Layer Sandwich	RNA Cap, Translation Initiation Factor Eif4e	RNA Cap, Translation Initiation Factor Eif4e	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF01652	Eukaryotic initiation factor 4E (IF4E)	Eukaryotic initiation factor 4E	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding protein binding translation initiation factor binding eukaryotic initiation factor 4G binding RNA binding RNA 7-methylguanosine cap binding RNA cap binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process cellular process protein metabolic process macromolecule metabolic process nucleobase-containing compound metabolic process RNA metabolic process nucleic acid metabolic process	neuromuscular junction synapse cell junction cellular anatomical entity neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection neuromuscular junction synapse cell junction cellular anatomical entity neuron projection cytoplasm intracellular anatomical structure cytoplasmic ribonucleoprotein granule neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule intracellular organelle cell projection organelle neuronal ribonucleoprotein granule intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle muscle cell postsynaptic specialization postsynapse postsynaptic specialization postsynapse of neuromuscular junction cytosol P-body protein-containing complex eukaryotic translation initiation factor 4F complex RNA cap binding complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
B	EUKARYOTIC TRANSLATION INITIATION FACTOR 4G, ISOFORM A	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding mRNA binding RNA 7-methylguanosine cap binding RNA cap binding eukaryotic initiation factor 4E binding protein binding translation initiation factor binding	cellular process cell cycle mitotic cell cycle organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process cellular process cell cycle mitotic cell cycle organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex eukaryotic translation initiation factor 4F complex RNA cap binding complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR019770	Eukaryotic translation initiation factor 4E (eIF-4E), conserved site	Conserved Site
A, C	IPR023398	Translation Initiation factor eIF- 4e-like	Homologous Superfamily
A, C	IPR001040	Translation Initiation factor eIF- 4e	Family
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR003307	W2 domain	Domain
B	IPR003891	Initiation factor eIF-4 gamma, MA3	Domain
B	IPR045208	Initiation factor 4G	Family
B	IPR003890	MIF4G-like, type 3	Domain
B	IPR049485	Translation initiation factor eIF4G-like, eIF4E-binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.