5D6F

Structure of human methionine aminopeptidase-2 complexed with spiroepoxytriazole inhibitor (+)-31b

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Winged helix DNA-binding domain	8056279	3000034	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Creatinase/aminopeptidase catalytic domain-like	8056277	3000126	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Creatinase/aminopeptidase catalytic domain-like	8056277	3000126	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	crvDNA_42K	e5d6fA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: crvDNA_42K	ECOD (1.6)
A	Peptidase_M24	e5d6fA1	A: a+b duplicates or obligate multimers	X: Creatinase/aminopeptidase-like	H: Creatinase/aminopeptidase (From Topology)	T: Creatinase/aminopeptidase	F: Peptidase_M24	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.230.10	Alpha Beta	Alpha-Beta Complex	Creatine Amidinohydrolase	Creatinase/methionine aminopeptidase superfamily	CATH (4.3.0)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00557	Metallopeptidase family M24 (Peptidase_M24)	Metallopeptidase family M24	This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Methionine aminopeptidase 2	peptidase activity catalytic activity, acting on a protein initiator methionyl aminopeptidase activity aminopeptidase activity hydrolase activity exopeptidase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding metallopeptidase activity metalloaminopeptidase activity metalloexopeptidase activity peptidase activity catalytic activity, acting on a protein initiator methionyl aminopeptidase activity aminopeptidase activity hydrolase activity exopeptidase activity catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding metallopeptidase activity metalloaminopeptidase activity metalloexopeptidase activity cation binding ion binding metal ion binding small molecule binding	N-terminal protein amino acid modification macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process peptidyl-methionine modification peptidyl-amino acid modification gene expression macromolecule biosynthetic process protein maturation biosynthetic process N-terminal protein amino acid modification macromolecule modification metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process peptidyl-methionine modification peptidyl-amino acid modification gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001714	Peptidase M24, methionine aminopeptidase	Family
A	IPR050247	Methionine Aminopeptidase Type 2	Family
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A	IPR002468	Peptidase M24A, methionine aminopeptidase, subfamily 2	Family
A	IPR018349	Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site	Binding Site
A	IPR036005	Creatinase/aminopeptidase-like	Homologous Superfamily
A	IPR000994	Peptidase M24	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P50579	astrocytic tumor IgA glomerulonephritis malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma plasma cell myeloma rheumatoid arthritis breast cancer large cell medulloblastoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor tuberculosis glioblastoma astrocytic tumor IgA glomerulonephritis malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma plasma cell myeloma rheumatoid arthritis breast cancer large cell medulloblastoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor tuberculosis glioblastoma malignant ependymoma myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.