5ER8

Crystal structure of cyclization domain of Phomopsis amygdali fusicoccadiene synthase complexed with manganese ions and neridronate

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Terpene_synth_C	e5er8A1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: Terpene_synth_C	ECOD (1.6)
B	Terpene_synth_C	e5er8B1	A: alpha bundles	X: Terpenoid synthases (From Topology)	H: Terpenoid synthases (From Topology)	T: Terpenoid synthases	F: Terpene_synth_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)
B	1.10.600.10	Mainly Alpha	Orthogonal Bundle	Farnesyl Diphosphate Synthase	Farnesyl Diphosphate Synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF19086	Terpene synthase family 2, C-terminal metal binding (Terpene_syn_C_2)	Terpene synthase family 2, C-terminal metal binding	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Fusicoccadiene synthase	farnesyltranstransferase activity prenyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity lyase activity cation binding ion binding binding metal ion binding small molecule binding	biosynthetic process small molecule biosynthetic process ketone metabolic process metabolic process cellular process small molecule metabolic process ketone biosynthetic process mycotoxin metabolic process secondary metabolite biosynthetic process mycotoxin biosynthetic process toxin biosynthetic process toxin metabolic process secondary metabolic process isoprenoid biosynthetic process biosynthetic process small molecule biosynthetic process ketone metabolic process metabolic process cellular process small molecule metabolic process ketone biosynthetic process mycotoxin metabolic process secondary metabolite biosynthetic process mycotoxin biosynthetic process toxin biosynthetic process toxin metabolic process secondary metabolic process isoprenoid biosynthetic process lipid biosynthetic process primary metabolic process lipid metabolic process isoprenoid metabolic process organic hydroxy compound biosynthetic process organic hydroxy compound metabolic process alcohol biosynthetic process alcohol metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000092	Polyprenyl synthetase	Family
A, B	IPR008949	Isoprenoid synthase domain superfamily	Homologous Superfamily
A, B	IPR033749	Polyprenyl synthetase, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.