5ES7

Crystal structure of the F-A domains of the LgrA initiation module soaked with FON, AMPcPP, and valine.

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAMP-binding_3rde5es7A2 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
AFormyl_trans_Ne5es7A4 A: a/b three-layered sandwichesX: Formyltransferase (From Topology)H: Formyltransferase (From Topology)T: FormyltransferaseF: Formyl_trans_NECOD (1.6)
AAMP-binding_1ste5es7A1 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
AAMP-binding_2nde5es7A3 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00501AMP-binding enzyme (AMP-binding)AMP-binding enzyme- Family
PF00551Formyl transferase (Formyl_trans_N)Formyl transferaseThis family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces ...This family includes the following members. Glycinamide ribonucleotide transformylase catalyses the third step in de novo purine biosynthesis, the transfer of a formyl group to 5'-phosphoribosylglycinamide. Formyltetrahydrofolate deformylase produces formate from formyl- tetrahydrofolate. Methionyl-tRNA formyltransferase transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. Inclusion of the following members is supported by PSI-blast. HOXX_BRAJA (P31907) contains a related domain of unknown function. PRTH_PORGI (P46071) contains a related domain of unknown function. Y09P_MYCTU (Q50721) contains a related domain of unknown function.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Linear gramicidin synthetase subunit A

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR006162Phosphopantetheine attachment sitePTM
IPR009081Phosphopantetheine binding ACP domainDomain
IPR010071Amino acid adenylation domainDomain
IPR036477Formyl transferase, N-terminal domain superfamilyHomologous Superfamily
IPR020845AMP-binding, conserved siteConserved Site
IPR023213Chloramphenicol acetyltransferase-like domain superfamilyHomologous Superfamily
IPR010060Non-ribosomal peptide synthaseDomain
IPR045851AMP-binding enzyme, C-terminal domain superfamilyHomologous Superfamily
IPR020806Polyketide synthase, phosphopantetheine-binding domainDomain
IPR001242Condensation domainDomain
IPR036736ACP-like superfamilyHomologous Superfamily
IPR002376Formyl transferase, N-terminalDomain
IPR025110AMP-binding enzyme, C-terminal domainDomain
IPR000873AMP-dependent synthetase/ligase domainDomain