5EX4

3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with tryptophan in all three allosteric binding sites

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5ex4a_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class-II DAHP synthetase	Probable DAHP synthetase AroG, phenylalanine-repressible	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d5ex4b1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class-II DAHP synthetase	Probable DAHP synthetase AroG, phenylalanine-repressible	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d5ex4b2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Aldolase	8037699	3000445	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Aldolase	8037699	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DAHP_synth_2	e5ex4A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DAHP_synth_2	ECOD (1.6)
B	DAHP_synth_2	e5ex4B1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DAHP_synth_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01474	Class-II DAHP synthetase family (DAHP_synth_2)	Class-II DAHP synthetase family	Members of this family are aldolase enzymes that catalyse the first step of the shikimate pathway.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3-deoxy-D-arabinoheptulosonate-7-phosphate synthase	cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding transferase activity 3-deoxy-7-phosphoheptulonate synthase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity	amino acid biosynthetic process biosynthetic process amino acid metabolic process primary metabolic process metabolic process cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis amino acid biosynthetic process biosynthetic process amino acid metabolic process primary metabolic process metabolic process cellular process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis small molecule biosynthetic process oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process chorismate metabolic process chorismate biosynthetic process small molecule metabolic process dicarboxylic acid biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002480	DAHP synthetase, class II	Family
A, B	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.