Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFlu_PA_Ce5fmzA1 A: a+b complex topologyX: Polymerase acidic protein (From Topology)H: Polymerase acidic protein (From Topology)T: Polymerase acidic proteinF: Flu_PA_CECOD (1.6)
AFlu_PA_Ne5fmzA2 A: a/b three-layered sandwichesX: Restriction endonuclease-likeH: Restriction endonuclease-like (From Topology)T: Restriction endonuclease-likeF: Flu_PA_NECOD (1.6)
DFlu_PA_Ce5fmzD2 A: a+b complex topologyX: Polymerase acidic protein (From Topology)H: Polymerase acidic protein (From Topology)T: Polymerase acidic proteinF: Flu_PA_CECOD (1.6)
DFlu_PA_Ne5fmzD1 A: a/b three-layered sandwichesX: Restriction endonuclease-likeH: Restriction endonuclease-like (From Topology)T: Restriction endonuclease-likeF: Flu_PA_NECOD (1.6)
BFlu_PB1_2nde5fmzB2 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: Flu_PB1_2ndECOD (1.6)
BFlu_PB1_1ste5fmzB3 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: Flu_PB1_1stECOD (1.6)
BFlu_PB1_3rde5fmzB1 A: extended segmentsX: RNA polymerase PB1 C-terminal fragment (From Topology)H: RNA polymerase PB1 C-terminal fragment (From Topology)T: RNA polymerase PB1 C-terminal fragmentF: Flu_PB1_3rdECOD (1.6)
EFlu_PB1_2nde5fmzE3 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: Flu_PB1_2ndECOD (1.6)
EFlu_PB1_1ste5fmzE1 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: Flu_PB1_1stECOD (1.6)
EFlu_PB1_3rde5fmzE2 A: extended segmentsX: RNA polymerase PB1 C-terminal fragment (From Topology)H: RNA polymerase PB1 C-terminal fragment (From Topology)T: RNA polymerase PB1 C-terminal fragmentF: Flu_PB1_3rdECOD (1.6)
CFlu_PB2_6the5fmzC6 A: alpha arraysX: PB2 '627' domain-related (From Homology)H: PB2 '627' domain-relatedT: Polymerase basic protein 2 (PB2) '627' domainF: Flu_PB2_6thECOD (1.6)
CFlu_PB2_4the5fmzC7 A: alpha arraysX: Helical domain in PB2 (From Topology)H: Helical domain in PB2 (From Topology)T: Helical domain in PB2F: Flu_PB2_4thECOD (1.6)
CFlu_PB2_7the5fmzC5 A: a+b two layersX: PB2 C-terminal domain-like (From Topology)H: PB2 C-terminal domain-like (From Topology)T: PB2 C-terminal domain-likeF: Flu_PB2_7thECOD (1.6)
CFlu_PB2_2nde5fmzC2 A: a+b two layersX: a+b domain in PB2 (From Topology)H: a+b domain in PB2 (From Topology)T: a+b domain in PB2F: Flu_PB2_2ndECOD (1.6)
CFlu_PB2_5the5fmzC3 A: a+b three layersX: Polymerase basic protein 2 cap-binding domain (From Topology)H: Polymerase basic protein 2 cap-binding domain (From Topology)T: Polymerase basic protein 2 cap-binding domainF: Flu_PB2_5thECOD (1.6)
CFlu_PB2_3rde5fmzC1 A: a+b complex topologyX: Middle domain in PB2 (From Topology)H: Middle domain in PB2 (From Topology)T: Middle domain in PB2F: Flu_PB2_3rdECOD (1.6)
CFlu_PB2_1ste5fmzC4 A: extended segmentsX: RNA polymerase PB2 N-terminal fragment (From Topology)H: RNA polymerase PB2 N-terminal fragment (From Topology)T: RNA polymerase PB2 N-terminal fragmentF: Flu_PB2_1stECOD (1.6)
FFlu_PB2_6the5fmzF6 A: alpha arraysX: PB2 '627' domain-related (From Homology)H: PB2 '627' domain-relatedT: Polymerase basic protein 2 (PB2) '627' domainF: Flu_PB2_6thECOD (1.6)
FFlu_PB2_4the5fmzF3 A: alpha arraysX: Helical domain in PB2 (From Topology)H: Helical domain in PB2 (From Topology)T: Helical domain in PB2F: Flu_PB2_4thECOD (1.6)
FFlu_PB2_7the5fmzF1 A: a+b two layersX: PB2 C-terminal domain-like (From Topology)H: PB2 C-terminal domain-like (From Topology)T: PB2 C-terminal domain-likeF: Flu_PB2_7thECOD (1.6)
FFlu_PB2_2nde5fmzF2 A: a+b two layersX: a+b domain in PB2 (From Topology)H: a+b domain in PB2 (From Topology)T: a+b domain in PB2F: Flu_PB2_2ndECOD (1.6)
FFlu_PB2_5the5fmzF5 A: a+b three layersX: Polymerase basic protein 2 cap-binding domain (From Topology)H: Polymerase basic protein 2 cap-binding domain (From Topology)T: Polymerase basic protein 2 cap-binding domainF: Flu_PB2_5thECOD (1.6)
FFlu_PB2_3rde5fmzF7 A: a+b complex topologyX: Middle domain in PB2 (From Topology)H: Middle domain in PB2 (From Topology)T: Middle domain in PB2F: Flu_PB2_3rdECOD (1.6)
FFlu_PB2_1ste5fmzF4 A: extended segmentsX: RNA polymerase PB2 N-terminal fragment (From Topology)H: RNA polymerase PB2 N-terminal fragment (From Topology)T: RNA polymerase PB2 N-terminal fragmentF: Flu_PB2_1stECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, D
PF00603Influenza RNA-dependent RNA polymerase subunit PA (Flu_PA)Influenza RNA-dependent RNA polymerase subunit PA- Family
B, E
PF00602Influenza RNA-dependent RNA polymerase subunit PB1 (Flu_PB1)Influenza RNA-dependent RNA polymerase subunit PB1- Family
C, F
PF20948Influenza RNA polymerase PB2 second domain (Flu_PB2_2nd)Influenza RNA polymerase PB2 second domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the domain of the Flu PB protein that follows the N-terminal extended region.
Domain
C, F
PF00604Influenza RNA polymerase PB2 CAP binding domain (Flu_PB2_5th)Influenza RNA polymerase PB2 CAP binding domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the CAP binding domain [2].
Domain
C, F
PF20947Influenza RNA polymerase PB2 N-terminal region (Flu_PB2_1st)Influenza RNA polymerase PB2 N-terminal region- Family
C, F
PF20949Influenza RNA polymerase PB2 middle domain (Flu_PB2_3rd)Influenza RNA polymerase PB2 middle domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the middle domain in Flu PB2 protein.
Domain
C, F
PF20951Influenza RNA polymerase PB2 6th domain (Flu_PB2_6th)Influenza RNA polymerase PB2 6th domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the 6th domain of PB2.
Domain
C, F
PF20950Influenza RNA polymerase PB2 helical domain (Flu_PB2_4th)Influenza RNA polymerase PB2 helical domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the helical domain of Flu PB2 protein.
Domain
C, F
PF20952Influenza RNA polymerase PB2 C-terminal domain (Flu_PB2_7th)Influenza RNA polymerase PB2 C-terminal domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the C-terminal domain of Flu PB2 protein.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, D
POLYMERASE ACIDIC PROTEIN
B, E
RNA-DIRECTED RNA POLYMERASE CATALYTIC SUBUNIT
C, F
POLYMERASE BASIC PROTEIN 2
G [auth H],
H [auth V]
5'-R(*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP)-3'---