5GH0

Crystal structure of the complex of bovine lactoperoxidase with mercaptoimidazole at 2.3 A resolution

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	An_peroxidase	e5gh0A1	A: alpha complex topology	X: Heme-dependent peroxidases (From Topology)	H: Heme-dependent peroxidases (From Topology)	T: Heme-dependent peroxidases	F: An_peroxidase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.640.10	Mainly Alpha	Orthogonal Bundle	Myeloperoxidase, subunit C	Haem peroxidase domain superfamily, animal type	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03098	Animal haem peroxidase (An_peroxidase)	Animal haem peroxidase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Lactoperoxidase	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity organic cyclic compound binding tetrapyrrole binding heme binding lactoperoxidase activity thiocyanate peroxidase activity	catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response antibacterial humoral response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to bacterium defense response to other organism response to stress immune system process response to bacterium response to external biotic stimulus response to oxidative stress	cellular anatomical structure intracellular anatomical structure cytoplasm extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019791	Haem peroxidase, animal-type	Family
A	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
A	IPR050702	Peroxidase/ROS_Generation	Unknown
A	IPR010255	Haem peroxidase superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.