Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AUB2He5hlaA2 A: beta meandersX: Colicin E3 ribonuclease domain-likeH: UvrB interaction domain (From Topology)T: UvrB interaction domainF: UB2HECOD (1.6)
ATranspeptidase_1st_1e5hlaA4 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_1st_1ECOD (1.6)
ATranspeptidase_2nde5hlaA1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_2ndECOD (1.6)
ATransglye5hlaA3 A: a+b complex topologyX: Lysozyme-like (From Homology)H: Lysozyme-likeT: Lysozyme-likeF: TransglyECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF14814Bifunctional transglycosylase second domain (UB2H)Bifunctional transglycosylase second domainUB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is un ...UB2H is the second domain of the transglycosylases, or penicillin-binding proteins PBP1bs)), the multi-domain membrane proteins essential for cell wall synthesis that are targeted by penicillin antibiotics. The exact function of the UB2H domain is uncertain, but it may act as the binding component of PBP1b with different binding partners, or it may participate in the regulation between DNA repair and/or synthesis and cell wall formation during the bacterial cell cycle [1].
Domain
PF00912Transglycosylase (Transgly)Transglycosylase- Family
PF00905Penicillin binding protein transpeptidase domain (Transpeptidase)Penicillin binding protein transpeptidase domainThe active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Penicillin-binding protein 1B

Membrane Protein Annotation: PDBTM PDBTM Database Homepage