5HUT

Structure of Candida albicans trehalose-6-phosphate synthase in complex with UDP-glucose

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5hutb_	Alpha and beta proteins (a/b)	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	automated matches	automated matches	Yeast (Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)
A	d5huta_	Alpha and beta proteins (a/b)	UDP-Glycosyltransferase/glycogen phosphorylase	UDP-Glycosyltransferase/glycogen phosphorylase	automated matches	automated matches	Yeast (Candida albicans SC5314 ) [TaxId: 237561 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Type B glycosyltransferase-like	8079962	3001586	SCOP2B (2022-06-29)
A	SCOP2 Family	Trehalose-6-phosphate synthase, OtsA	8079961	4003141	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Type B glycosyltransferase-like	8079962	3001586	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Glyco_transf_20_N	e5hutB1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_20_N	ECOD (1.6)
B	Glyco_transf_20_C	e5hutB2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_20_C	ECOD (1.6)
A	Glyco_transf_20_N	e5hutA1	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_20_N	ECOD (1.6)
A	Glyco_transf_20_C	e5hutA2	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_20_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)
A	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00982	Glycosyltransferase family 20 (Glyco_transf_20)	Glycosyltransferase family 20	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha,alpha-trehalose-phosphate synthase [UDP-forming]	phosphoric ester hydrolase activity trehalose-phosphatase activity hydrolase activity, acting on ester bonds carbohydrate phosphatase activity phosphatase activity hydrolase activity catalytic activity sugar-phosphatase activity UDP-glycosyltransferase activity glycosyltransferase activity alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity transferase activity glucosyltransferase activity hexosyltransferase activity phosphoric ester hydrolase activity trehalose-phosphatase activity hydrolase activity, acting on ester bonds carbohydrate phosphatase activity phosphatase activity hydrolase activity catalytic activity sugar-phosphatase activity UDP-glycosyltransferase activity glycosyltransferase activity alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity transferase activity glucosyltransferase activity hexosyltransferase activity UDP-glucosyltransferase activity	response to stimulus response to stress filamentous growth of a population of unicellular organisms in response to heat growth response to heat response to abiotic stimulus filamentous growth response to temperature stimulus filamentous growth of a population of unicellular organisms carbohydrate metabolic process trehalose metabolic process carbohydrate biosynthetic process oligosaccharide metabolic process primary metabolic process response to stimulus response to stress filamentous growth of a population of unicellular organisms in response to heat growth response to heat response to abiotic stimulus filamentous growth response to temperature stimulus filamentous growth of a population of unicellular organisms carbohydrate metabolic process trehalose metabolic process carbohydrate biosynthetic process oligosaccharide metabolic process primary metabolic process disaccharide metabolic process disaccharide biosynthetic process biosynthetic process oligosaccharide biosynthetic process trehalose biosynthetic process metabolic process cellular process cellular response to stimulus cellular response to acid chemical cellular response to desiccation response to oxygen-containing compound cellular response to water deprivation response to water cellular response to oxygen-containing compound cellular response to environmental stimulus response to acid chemical cellular response to chemical stimulus cellular response to stress cellular response to water stimulus response to chemical cellular response to abiotic stimulus response to desiccation response to water deprivation trehalose metabolism in response to stress cellular response to heat filamentous growth of a population of unicellular organisms in response to biotic stimulus response to biotic stimulus	protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) transferase complex cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012766	Alpha,alpha-trehalose-phosphate synthase	Family
A, B	IPR001830	Glycosyl transferase, family 20	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.