5I56

Agonist-bound GluN1/GluN2A agonist binding domains with TCN201

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd5i56b_ Alpha and beta proteins (a/b) Periplasmic binding protein-like II Periplasmic binding protein-like II automated matches automated matches Rat (Rattus norvegicus ) [TaxId: 10116 ], Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ad5i56a_ Alpha and beta proteins (a/b) Periplasmic binding protein-like II Periplasmic binding protein-like II Phosphate binding protein-like N-methyl-D-aspartate receptor subunit 1 Rat (Rattus norvegicus ) [TaxId: 10116 ], Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyType 2 solute binding protein-like 8036603 3000083 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BSBP_bac_3_1ste5i56B1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: SBP_bac_3_1stECOD (1.6)
BLig_chan_5e5i56B2 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: Lig_chan_5ECOD (1.6)
ASBP_bac_3_1ste5i56A1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: SBP_bac_3_1stECOD (1.6)
ALig_chan_1e5i56A2 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: Lig_chan_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein domain 2CATH (4.3.0)
A3.40.190.10 Alpha Beta 3-Layer(aba) Sandwich D-Maltodextrin-Binding Protein domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
PF10613Ligated ion channel L-glutamate- and glycine-binding site (Lig_chan-Glu_bd)Ligated ion channel L-glutamate- and glycine-binding siteThis region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF ...This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.
Domain
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
PF10613Ligated ion channel L-glutamate- and glycine-binding site (Lig_chan-Glu_bd)Ligated ion channel L-glutamate- and glycine-binding siteThis region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF ...This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A
Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR018884Glutamate [NMDA] receptor, epsilon subunit, C-terminalDomain
IPR028082Periplasmic binding protein-like IHomologous Superfamily
IPR001828Receptor, ligand binding regionDomain
IPR001320Ionotropic glutamate receptor, C-terminalDomain
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
IPR001508Ionotropic glutamate receptor, metazoaFamily
IPR015683Ionotropic glutamate receptorFamily
IPR028082Periplasmic binding protein-like IHomologous Superfamily
IPR001828Receptor, ligand binding regionDomain
IPR001320Ionotropic glutamate receptor, C-terminalDomain
IPR049873Glutamate [NMDA] receptor subunit 1-like, N-terminal LIVBP-like domainDomain
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
IPR001508Ionotropic glutamate receptor, metazoaFamily
IPR015683Ionotropic glutamate receptorFamily
IPR049872Glutamate [NMDA] receptor subunit 1-like, ligand-binding domainDomain