5IZQ

Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Frizzled domain-like	8090921	3001950	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Folate_rec	e5izqD1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
A	Folate_rec	e5izqA1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
B	Folate_rec	e5izqB1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
C	Folate_rec	e5izqC1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
E	Folate_rec	e5izqE1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
F	Folate_rec	e5izqF1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
G	Folate_rec	e5izqG1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)
H	Folate_rec	e5izqH1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Folate_rec	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF03024	Folate receptor family (Folate_rec)	Folate receptor family	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins co ...	This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Folate receptor alpha	molecular transducer activity signaling receptor activity cargo receptor activity folic acid receptor activity amide binding organic acid binding binding modified amino acid binding vitamin binding ion binding organic cyclic compound binding folic acid binding anion binding carboxylic acid binding molecular transducer activity signaling receptor activity cargo receptor activity folic acid receptor activity amide binding organic acid binding binding modified amino acid binding vitamin binding ion binding organic cyclic compound binding folic acid binding anion binding carboxylic acid binding heterocyclic compound binding small molecule binding	multicellular organismal process cellular developmental process cardiac neural crest cell development involved in heart development heart morphogenesis neural crest cell development cell development mesenchyme development mesenchymal cell migration multicellular organism development neural crest cell migration involved in heart formation cell migration involved in heart formation cell differentiation ameboidal-type cell migration anatomical structure development multicellular organismal process cellular developmental process cardiac neural crest cell development involved in heart development heart morphogenesis neural crest cell development cell development mesenchyme development mesenchymal cell migration multicellular organism development neural crest cell migration involved in heart formation cell migration involved in heart formation cell differentiation ameboidal-type cell migration anatomical structure development cell migration animal organ morphogenesis animal organ formation cell motility neural crest cell migration system development developmental process stem cell development heart development neural crest cell differentiation heart formation animal organ development cell migration involved in heart development tissue development cardiocyte differentiation circulatory system development anatomical structure morphogenesis stem cell differentiation cardiac neural crest cell differentiation involved in heart development anatomical structure formation involved in morphogenesis cellular process mesenchymal cell differentiation cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of Wnt signaling pathway signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway biological regulation regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication signal transduction Wnt signaling pathway sperm-egg recognition sexual reproduction cell-cell recognition reproductive process fertilization cell recognition single fertilization cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway embryonic epithelial tube formation chordate embryonic development anterior neural tube closure tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue morphogenesis neural tube closure neural tube formation tube closure membrane organization membrane fusion plasma membrane fusion multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism cellular component organization fusion of sperm to egg plasma membrane involved in single fertilization plasma membrane organization cellular component organization or biogenesis endomembrane system organization oxoacid metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process modified amino acid metabolic process organic acid metabolic process vitamin metabolic process folic acid-containing compound metabolic process small molecule metabolic process metabolic process amide metabolic process water-soluble vitamin metabolic process pteridine-containing compound metabolic process folic acid metabolic process cell adhesion cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration neurogenesis axon regeneration neuron differentiation cellular response to stress response to stress response to wounding plasma membrane bounded cell projection organization axon development generation of neurons neuron development cardiac neural crest cell development involved in outflow tract morphogenesis outflow tract morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis organic anion transport nitrogen compound transport carboxylic acid transport transport vitamin transport establishment of localization organic acid transport localization amide transport folic acid transport dicarboxylic acid transport modified amino acid transport blood vessel morphogenesis artery development pharyngeal arch artery morphogenesis vasculature development pharyngeal system development artery morphogenesis blood vessel development cellular response to nitrogen compound response to nutrient levels response to nutrient response to folic acid cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound response to vitamin cellular response to oxygen-containing compound cellular response to nutrient levels cellular response to chemical stimulus cellular response to vitamin cellular response to folic acid response to chemical cellular response to nutrient response to organic cyclic compound pattern specification process embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation import into cell receptor-mediated endocytosis endocytosis vesicle-mediated transport	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane apical part of cell plasma membrane region apical plasma membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle basal part of cell basal plasma membrane basolateral plasma membrane transport vesicle endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane endosome Golgi membrane Golgi apparatus bounding membrane of organelle endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment brush border membrane cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell projection cell projection membrane transport vesicle membrane cytoplasmic vesicle membrane coated vesicle membrane COPII-coated ER to Golgi transport vesicle vesicle membrane ER to Golgi transport vesicle membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004269	Folate receptor	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR018143	Folate receptor-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H	Pharos: P15328	intellectual disability neurodegenerative syndrome due to cerebral folate transport deficiency epilepsy osteosarcoma ovarian cancer malignant colon neoplasm neural tube defect Brain Diseases, Metabolic, Inborn congenital abnormality diabetes mellitus pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma tethered spinal cord syndrome atypical teratoid rhabdoid tumor lung adenocarcinoma intellectual disability neurodegenerative syndrome due to cerebral folate transport deficiency epilepsy osteosarcoma ovarian cancer malignant colon neoplasm neural tube defect Brain Diseases, Metabolic, Inborn congenital abnormality diabetes mellitus pancreatic intraductal papillary-mucinous neoplasm invasive ductal breast carcinoma tethered spinal cord syndrome atypical teratoid rhabdoid tumor lung adenocarcinoma benign colon neoplasm breast cancer malignant mesothelioma colonic neoplasm congenital heart disease cutaneous lupus erythematosus non-small cell lung carcinoma diastematomyelia ovarian neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis iniencephaly large cell medulloblastoma lung cancer malignant ependymoma breast carcinoma movement disorder neurodegenerative disease endometriosis pancreatic intraductal papillary-mucinous carcinoma pituitary cancer glioblastoma leukodystrophy lung carcinoma malignant glioma craniorachischisis neurenteric cyst

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.