5JA2
EntF, a Terminal Nonribosomal Peptide Synthetase Module Bound to the non-Native MbtH-Like Protein PA2412
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | d5ja2b1 | Alpha and beta proteins (a+b) | MbtH/L9 domain-like | MbtH-like | MbtH-like | Uncharacterized protein PA2412 | (Pseudomonas aeruginosa PAO1 ) [TaxId: 208964 ], | SCOPe (2.08) |
B | d5ja2b2 | Artifacts | Tags | Tags | Tags | N-terminal Tags | (Pseudomonas aeruginosa PAO1 ) [TaxId: 208964 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | AMP-binding_3rd | e5ja2A8 | A: beta barrels | X: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | T: beta-barrel domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_3rd | ECOD (1.6) |
A | PP-binding | e5ja2A7 | A: alpha bundles | X: ACP-like | H: Acyl-carrier protein (ACP) (From Topology) | T: Acyl-carrier protein (ACP) | F: PP-binding | ECOD (1.6) |
A | AMP-binding_C | e5ja2A6 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: a+b domain in acetyl-CoA synthetase-like proteins (From Topology) | T: a+b domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_C | ECOD (1.6) |
A | Condensation_N | e5ja2A4 | A: a+b complex topology | X: CoA-dependent acyltransferases (From Topology) | H: CoA-dependent acyltransferases (From Topology) | T: CoA-dependent acyltransferases | F: Condensation_N | ECOD (1.6) |
A | Condensation_C_2 | e5ja2A1 | A: a+b complex topology | X: CoA-dependent acyltransferases (From Topology) | H: CoA-dependent acyltransferases (From Topology) | T: CoA-dependent acyltransferases | F: Condensation_C_2 | ECOD (1.6) |
A | Hydrolase_4_1 | e5ja2A2 | A: a/b three-layered sandwiches | X: alpha/beta-Hydrolases (From Topology) | H: alpha/beta-Hydrolases (From Topology) | T: alpha/beta-Hydrolases | F: Hydrolase_4_1 | ECOD (1.6) |
A | AMP-binding_1st | e5ja2A5 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_1st | ECOD (1.6) |
A | AMP-binding_2nd | e5ja2A9 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_2nd | ECOD (1.6) |
B | MbtH | e5ja2B1 | A: a+b two layers | X: L9 N-domain-like | H: MbtH-like (From Topology) | T: MbtH-like | F: MbtH | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00501 | AMP-binding enzyme (AMP-binding) | AMP-binding enzyme | - | Family | |
PF00975 | Thioesterase domain (Thioesterase) | Thioesterase domain | Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of v ... | Domain | |
PF00550 | Phosphopantetheine attachment site (PP-binding) | Phosphopantetheine attachment site | A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ... | Domain | |
PF03621 | MbtH-like protein (MbtH) | MbtH-like protein | This domain is found in the MbtH protein Swiss:O05821 as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologues were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR006162 | Phosphopantetheine attachment site | PTM | |
IPR009081 | Phosphopantetheine binding ACP domain | Domain | |
IPR010071 | Amino acid adenylation domain | Domain | |
IPR029058 | Alpha/Beta hydrolase fold | Homologous Superfamily | |
IPR020845 | AMP-binding, conserved site | Conserved Site | |
IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily | Homologous Superfamily | |
IPR020802 | Polyketide synthase, thioesterase domain | Domain | |
IPR045851 | AMP-binding enzyme, C-terminal domain superfamily | Homologous Superfamily | |
IPR020806 | Polyketide synthase, phosphopantetheine-binding domain | Domain | |
IPR001242 | Condensation domain | Domain | |
IPR036736 | ACP-like superfamily | Homologous Superfamily | |
IPR000873 | AMP-dependent synthetase/ligase domain | Domain | |
IPR001031 | Thioesterase | Domain | |
IPR038020 | MbtH-like domain superfamily | Homologous Superfamily | |
IPR037407 | MbtH-like protein | Family | |
IPR005153 | MbtH-like domain | Domain |