5JZN

Crystal structure of DCLK1-KD in complex with NVP-TAE684

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5jznb_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5jzna_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062424	3000066	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8062424	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Pkinase_Tyr	e5jznB1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
A	Pkinase_Tyr	e5jznA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Serine/threonine-protein kinase DCLK1	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity	developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation cellular component organization or biogenesis plasma membrane bounded cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process axonogenesis central nervous system neuron development central nervous system neuron differentiation central nervous system projection neuron axonogenesis central nervous system neuron axonogenesis axon development head development forebrain development animal organ development brain development localization cellular localization transport establishment of localization in cell intracellular transport establishment of localization vesicle-mediated transport endosomal transport protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus axon extension developmental growth cell growth neuron projection extension developmental cell growth growth developmental growth involved in morphogenesis neuron migration cell migration cell motility protein localization regulation of localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation negative regulation of biological process regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle negative regulation of cellular process negative regulation of protein localization cellular response to stimulus signaling signal transduction intracellular signal transduction cell communication	cell periphery cellular anatomical structure plasma membrane membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization organelle synapse cell junction asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR036572	Doublecortin domain superfamily	Homologous Superfamily
A, B	IPR003533	Doublecortin domain	Domain
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O15075	colorectal cancer IgA glomerulonephritis juvenile dermatomyositis lung cancer malignant ependymoma amyotrophic lateral sclerosis medulloblastoma atypical teratoid rhabdoid tumor ovarian cancer breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma colorectal carcinoma primitive neuroectodermal tumor diabetes mellitus colorectal cancer IgA glomerulonephritis juvenile dermatomyositis lung cancer malignant ependymoma amyotrophic lateral sclerosis medulloblastoma atypical teratoid rhabdoid tumor ovarian cancer breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma colorectal carcinoma primitive neuroectodermal tumor diabetes mellitus Sjogren syndrome ductal breast carcinoma in situ gastric adenocarcinoma interstitial cystitis large cell medulloblastoma lung carcinoma malignant glioma astrocytic tumor myopathy Becker muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma Parkinson disease breast carcinoma pituitary cancer Colorectal Neoplasms psoriasis Down syndrome subependymal giant cell astrocytoma Emery-Dreifuss muscular dystrophy glioblastoma invasive ductal breast carcinoma limb-girdle muscular dystrophy malignant colon neoplasm malignant mesothelioma atopic eczema oligodendroglioma bipolar disorder pancreatic intraductal papillary-mucinous neoplasm Pick disease plasma cell myeloma cystic fibrosis schizophrenia Duchenne muscular dystrophy facioscapulohumeral muscular dystrophy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.