5K09

Crystal Structure of COMT in complex with a thiazole ligand


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad5k09a1 Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ad5k09a2 Artifacts Tags Tags Tags C-terminal Tags Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Bd5k09b_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Cd5k09c_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Dd5k09d_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ed5k09e_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Fd5k09f_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Gd5k09g1 Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Gd5k09g2 Artifacts Tags Tags Tags C-terminal Tags Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Hd5k09h_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Id5k09i_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Jd5k09j_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Kd5k09k_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ld5k09l_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Md5k09m_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Nd5k09n_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Od5k09o_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Pd5k09p_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Qd5k09q_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Rd5k09r1 Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Rd5k09r2 Artifacts Tags Tags Tags C-terminal Tags Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Sd5k09s_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Td5k09t_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Ud5k09u_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Vd5k09v_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Wd5k09w_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)
Xd5k09x_ Alpha and beta proteins (a/b) S-adenosyl-L-methionine-dependent methyltransferases S-adenosyl-L-methionine-dependent methyltransferases COMT-like Catechol O-methyltransferase, COMT Norway Rat (Rattus norvegicus ) [TaxId: 10116 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
JSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
LSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
NSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
OSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
PSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
QSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
RSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
SSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
TSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
USCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
VSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
WSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)
XSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8039015 3000118 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMethyltransf_11_4e5k09A1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
BMethyltransf_11_4e5k09B1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
CMethyltransf_11_4e5k09C1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
DMethyltransf_11_4e5k09D1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
EMethyltransf_11_4e5k09E1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
FMethyltransf_11_4e5k09F1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
GMethyltransf_11_4e5k09G1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
HMethyltransf_11_4e5k09H1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
IMethyltransf_11_4e5k09I1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
JMethyltransf_11_4e5k09J1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
KMethyltransf_11_4e5k09K1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
LMethyltransf_11_4e5k09L1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
MMethyltransf_11_4e5k09M1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
NMethyltransf_11_4e5k09N1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
OMethyltransf_11_4e5k09O1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
PMethyltransf_11_4e5k09P1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
QMethyltransf_11_4e5k09Q1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
RMethyltransf_11_4e5k09R1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
SMethyltransf_11_4e5k09S1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
TMethyltransf_11_4e5k09T1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
UMethyltransf_11_4e5k09U1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
VMethyltransf_11_4e5k09V1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
WMethyltransf_11_4e5k09W1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)
XMethyltransf_11_4e5k09X1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_4ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
B3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
C3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
D3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
E3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
F3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
G3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
H3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
I3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
J3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
K3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
L3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
M3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
N3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
O3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
P3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
Q3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
R3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
S3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
T3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
U3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
V3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
W3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
X3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF01596O-methyltransferase (Methyltransf_3)O-methyltransferaseMembers of this family are O-methyltransferases. The family includes catechol o-methyltransferase Swiss:P21964, caffeoyl-CoA O-methyltransferase Swiss:Q43095 and a family of bacterial O-methyltransferases that may be involved in antibiotic production ...Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase Swiss:P21964, caffeoyl-CoA O-methyltransferase Swiss:Q43095 and a family of bacterial O-methyltransferases that may be involved in antibiotic production [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Catechol O-methyltransferase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR002935Class I-like SAM-dependent O-methyltransferaseFamily
A, B, C, D, E
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, B, C, D, E
IPR017128Catechol O-methyltransferase, eukaryoticFamily