5LHD

Structure of glycosylated human aminopeptidase N

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5lhda4	All alpha proteins	alpha-alpha superhelix	ARM repeat	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5lhda3	All beta proteins	Immunoglobulin-like beta-sandwich	Zn aminopeptidase insert domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5lhda1	All beta proteins	Zn aminopeptidase N-terminal domain	Zn aminopeptidase N-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5lhda2	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5lhdb4	All alpha proteins	alpha-alpha superhelix	ARM repeat	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5lhdb3	All beta proteins	Immunoglobulin-like beta-sandwich	Zn aminopeptidase insert domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5lhdb1	All beta proteins	Zn aminopeptidase N-terminal domain	Zn aminopeptidase N-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5lhdb2	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5lhdc4	All alpha proteins	alpha-alpha superhelix	ARM repeat	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5lhdc3	All beta proteins	Immunoglobulin-like beta-sandwich	Zn aminopeptidase insert domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5lhdc1	All beta proteins	Zn aminopeptidase N-terminal domain	Zn aminopeptidase N-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5lhdc2	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5lhdd4	All alpha proteins	alpha-alpha superhelix	ARM repeat	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5lhdd3	All beta proteins	Immunoglobulin-like beta-sandwich	Zn aminopeptidase insert domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5lhdd1	All beta proteins	Zn aminopeptidase N-terminal domain	Zn aminopeptidase N-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d5lhdd2	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ERAP1, insert domain	8054110	3002272	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8054109	3001975	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8054111	3000116	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8054108	3000390	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8054111	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ERAP1, insert domain	8054110	3002272	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8054108	3000390	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8054109	3001975	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ARM repeat-like	8054111	3000116	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8054109	3001975	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ERAP1, insert domain	8054110	3002272	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8054108	3000390	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Metalloproteases (zincins), catalytic domain	8054109	3001975	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8054108	3000390	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ERAP1, insert domain	8054110	3002272	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ARM repeat-like	8054111	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ERAP1_C	e5lhdA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ERAP1_C	ECOD (1.6)
A	Peptidase_M1_2	e5lhdA4	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
A	ERAP1_C	e5lhdA3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ERAP1_C	ECOD (1.6)
A	Peptidase_M1	e5lhdA1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1	ECOD (1.6)
B	ERAP1_C	e5lhdB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ERAP1_C	ECOD (1.6)
B	Peptidase_M1_2	e5lhdB4	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
B	ERAP1_C	e5lhdB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ERAP1_C	ECOD (1.6)
B	Peptidase_M1	e5lhdB2	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1	ECOD (1.6)
C	ERAP1_C	e5lhdC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ERAP1_C	ECOD (1.6)
C	Peptidase_M1_2	e5lhdC4	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
C	ERAP1_C	e5lhdC3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ERAP1_C	ECOD (1.6)
C	Peptidase_M1	e5lhdC2	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1	ECOD (1.6)
D	ERAP1_C	e5lhdD4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ERAP1_C	ECOD (1.6)
D	Peptidase_M1_2	e5lhdD2	A: beta sandwiches	X: Baculovirus p35 protein-related (From Topology)	H: Baculovirus p35 protein-related (From Topology)	T: Baculovirus p35 protein-related	F: Peptidase_M1_2	ECOD (1.6)
D	ERAP1_C	e5lhdD3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ERAP1_C	ECOD (1.6)
D	Peptidase_M1	e5lhdD1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1730	Mainly Beta	Sandwich	Immunoglobulin-like	tricorn interacting facor f3 domain	CATH (4.3.0)
A	1.10.390.10	Mainly Alpha	Orthogonal Bundle	Neutral Protease	domain 2	CATH (4.3.0)
A	2.60.40.1910	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
A	1.25.50.20	Mainly Alpha	Alpha Horseshoe	Zincin-like fold		CATH (4.3.0)
B	2.60.40.1730	Mainly Beta	Sandwich	Immunoglobulin-like	tricorn interacting facor f3 domain	CATH (4.3.0)
B	1.10.390.10	Mainly Alpha	Orthogonal Bundle	Neutral Protease	domain 2	CATH (4.3.0)
B	2.60.40.1910	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	1.25.50.20	Mainly Alpha	Alpha Horseshoe	Zincin-like fold		CATH (4.3.0)
C	2.60.40.1730	Mainly Beta	Sandwich	Immunoglobulin-like	tricorn interacting facor f3 domain	CATH (4.3.0)
C	1.10.390.10	Mainly Alpha	Orthogonal Bundle	Neutral Protease	domain 2	CATH (4.3.0)
C	2.60.40.1910	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	1.25.50.20	Mainly Alpha	Alpha Horseshoe	Zincin-like fold		CATH (4.3.0)
D	2.60.40.1730	Mainly Beta	Sandwich	Immunoglobulin-like	tricorn interacting facor f3 domain	CATH (4.3.0)
D	1.10.390.10	Mainly Alpha	Orthogonal Bundle	Neutral Protease	domain 2	CATH (4.3.0)
D	2.60.40.1910	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	1.25.50.20	Mainly Alpha	Alpha Horseshoe	Zincin-like fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF11838	ERAP1-like C-terminal domain (ERAP1_C)	ERAP1-like C-terminal domain	This large domain is composed of 16 alpha helices organized as 8 HEAT-like repeats. This domain forms a concave face that faces towards the active site of the peptidase.	Domain
A, B, C, D	PF01433	Peptidase family M1 domain (Peptidase_M1)	Peptidase family M1 domain	Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activ ...	Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activity [1].	Domain
A, B, C, D	PF17900	Peptidase M1 N-terminal domain (Peptidase_M1_N)	Peptidase M1 N-terminal domain	This domain is found at the N-terminus of aminopeptidases from the M1 family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Aminopeptidase N	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity peptide binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular catabolic process catabolic process cellular metabolic process metabolic process cellular process peptide metabolic process peptide catabolic process developmental process cellular developmental process cell differentiation multicellular organismal process blood vessel morphogenesis tube development angiogenesis cellular catabolic process catabolic process cellular metabolic process metabolic process cellular process peptide metabolic process peptide catabolic process developmental process cellular developmental process cell differentiation multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development proteolysis primary metabolic process protein metabolic process macromolecule metabolic process	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle organelle membrane secretory granule membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome endoplasmic reticulum-Golgi intermediate compartment

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001930	Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase	Family
A, B, C, D	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy	Homologous Superfamily
A, B, C, D	IPR024571	ERAP1-like C-terminal domain	Domain
A, B, C, D	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
A, B, C, D	IPR034016	Aminopeptidase N-type	Family
A, B, C, D	IPR014782	Peptidase M1, membrane alanine aminopeptidase	Domain
A, B, C, D	IPR045357	Aminopeptidase N-like , N-terminal domain	Domain
A, B, C, D	IPR050344	Peptidase M1 family aminopeptidases	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P15144	urinary bladder cancer pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis urinary bladder neoplasm ACUTE ALCOHOL WITHDRAWAL Barrett esophagus cancer ductal breast carcinoma in situ major depressive disorder malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia acute myeloid leukemia breast cancer Crohn disease urinary bladder cancer pancreatic intraductal papillary-mucinous neoplasm ulcerative colitis urinary bladder neoplasm ACUTE ALCOHOL WITHDRAWAL Barrett esophagus cancer ductal breast carcinoma in situ major depressive disorder malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia acute myeloid leukemia breast cancer Crohn disease gallbladder disease malignant colon neoplasm nephrosclerosis pancreatic intraductal papillary-mucinous carcinoma tuberculosis atypical teratoid rhabdoid tumor breast carcinoma cystic fibrosis lung carcinoma malignant mesothelioma non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.