5LSU

Structure of the Epigenetic Oncogene MMSET and inhibition by N-Alkyl Sinefungin Derivatives

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5lsua_	Membrane and cell surface proteins and peptides	SNF-like	SNF-like	Amino acid antiporter-like	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5lsub_	Membrane and cell surface proteins and peptides	SNF-like	SNF-like	Amino acid antiporter-like	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SET	e5lsuA1	A: beta barrels	X: beta-clip	H: SET domain-like (From Topology)	T: SET domain-like	F: SET	ECOD (1.6)
A	AWS	e5lsuA2	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: AWS	ECOD (1.6)
B	SET	e5lsuB1	A: beta barrels	X: beta-clip	H: SET domain-like (From Topology)	T: SET domain-like	F: SET	ECOD (1.6)
B	AWS	e5lsuB2	A: few secondary structure elements	X: Zn3Cys9 preSET domain-related (From Topology)	H: Zn3Cys9 preSET domain-related (From Topology)	T: Zn3Cys9 preSET domain-related	F: AWS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.170.270.10	Mainly Beta	Beta Complex	Beta-clip-like	SET domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00856	SET domain (SET)	SET domain	-	Family
A, B	PF17907	AWS domain (AWS)	AWS domain	This entry represents the AWS (associated with SET domain) domain [1]. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET ...	This entry represents the AWS (associated with SET domain) domain [1]. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Histone-lysine N-methyltransferase NSD2	protein-lysine N-methyltransferase activity histone H4 methyltransferase activity histone H4K20 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity protein-lysine N-methyltransferase activity histone H4 methyltransferase activity histone H4K20 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity histone H3 methyltransferase activity chromatin binding binding histone H3K36 dimethyltransferase activity histone H3K36 methyltransferase activity sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding histone H3K36 trimethyltransferase activity cation binding ion binding metal ion binding small molecule binding	developmental process heart development multicellular organismal process cardiac atrium morphogenesis cardiac chamber morphogenesis atrial septum secundum morphogenesis animal organ development heart morphogenesis cardiac atrium development circulatory system development multicellular organism development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis cardiac chamber development developmental process heart development multicellular organismal process cardiac atrium morphogenesis cardiac chamber morphogenesis atrial septum secundum morphogenesis animal organ development heart morphogenesis cardiac atrium development circulatory system development multicellular organism development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis cardiac chamber development anatomical structure development atrial septum morphogenesis animal organ morphogenesis septum secundum development atrial septum development system development protein localization regulation of localization establishment of protein localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization regulation of establishment of protein localization biological regulation establishment of localization localization regulation of cellular localization cellular macromolecule localization macromolecule localization cellular process methylation metabolic process skeletal system development bone development ventricular septum development ventricular septum morphogenesis membranous septum morphogenesis cardiac ventricle development cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress regulation of double-strand break repair via nonhomologous end joining DNA repair double-strand break repair double-strand break repair via nonhomologous end joining DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process septum primum development atrial septum primum morphogenesis negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process positive regulation of immune response regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of isotype switching to IgA isotypes positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response immune response DNA recombination immune effector process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response immunoglobulin production regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination positive regulation of cellular metabolic process somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments positive regulation of biosynthetic process regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of cellular process production of molecular mediator of immune response positive regulation of immunoglobulin production regulation of isotype switching cell activation isotype switching to IgA isotypes positive regulation of gene expression immune system process somatic diversification of immune receptors via germline recombination within a single locus positive regulation of cellular biosynthetic process regulation of lymphocyte activation lymphocyte mediated immunity regulation of immune effector process regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response positive regulation of developmental process positive regulation of cell activation positive regulation of metabolic process positive regulation of leukocyte activation leukocyte mediated immunity somatic diversification of immune receptors positive regulation of adaptive immune response positive regulation of immune system process somatic recombination of immunoglobulin genes involved in immune response positive regulation of nucleobase-containing compound metabolic process regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins regulation of leukocyte mediated immunity regulation of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity regulation of isotype switching to IgA isotypes positive regulation of biological process lymphocyte activation positive regulation of B cell mediated immunity leukocyte activation positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of multicellular organismal process lymphocyte activation involved in immune response B cell activation immunoglobulin mediated immune response adaptive immune response positive regulation of B cell activation regulation of lymphocyte mediated immunity regulation of immunoglobulin production	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm nucleoplasm chromatin chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006560	AWS domain	Domain
A, B	IPR001965	Zinc finger, PHD-type	Domain
A, B	IPR046341	SET domain superfamily	Homologous Superfamily
A, B	IPR047441	Nuclear SET domain-containing protein 2, third PHD finger	Domain
A, B	IPR001214	SET domain	Domain
A, B	IPR000313	PWWP domain	Domain
A, B	IPR041306	NSD, Cys-His rich domain	Domain
A, B	IPR047426	Histone-lysine N-methyltransferase NSD1 / NSD2, first PHD finger	Domain
A, B	IPR050777	SET2 Histone-Lysine N-Methyltransferase	Family
A, B	IPR019787	Zinc finger, PHD-finger	Domain
A, B	IPR047442	Nuclear SET domain-containing protein 2, fifth PHD finger	Domain
A, B	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A, B	IPR003616	Post-SET domain	Domain
A, B	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
A, B	IPR047443	Nuclear SET domain-containing protein 2, HMG box	Domain
A, B	IPR047434	Nuclear SET domain-containing protein 2, first PWWP domain	Domain
A, B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B	IPR047437	Nuclear SET domain-containing protein 2, SET domain	Domain
A, B	IPR047439	Nuclear SET domain-containing protein 2, second PHD finger	Domain
A, B	IPR047435	Nuclear SET domain-containing protein 2, second PWWP domain	Domain
A, B	IPR001841	Zinc finger, RING-type	Domain
A, B	IPR009071	High mobility group box domain	Domain
A, B	IPR036910	High mobility group box domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O96028	Wolf-Hirschhorn syndrome breast carcinoma breast cancer Malignant neoplasm of breast medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer adrenal cortex carcinoma primitive neuroectodermal tumor bone marrow disease cancer ductal breast carcinoma in situ invasive ductal breast carcinoma lung adenocarcinoma Wolf-Hirschhorn syndrome breast carcinoma breast cancer Malignant neoplasm of breast medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer adrenal cortex carcinoma primitive neuroectodermal tumor bone marrow disease cancer ductal breast carcinoma in situ invasive ductal breast carcinoma lung adenocarcinoma malignant glioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm atopic eczema subependymal giant cell astrocytoma gastric carcinoma large cell medulloblastoma lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pilocytic astrocytoma atypical teratoid rhabdoid tumor childhood acute lymphoblastic leukemia glioblastoma malignant ependymoma