5N6R

Solution structure of the Dbl-homology domain of Bcr-Abl

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RhoGEF	e5n6rA1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00621	RhoGEF domain (RhoGEF)	RhoGEF domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Breakpoint cluster region protein	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine kinase activity protein serine/threonine kinase activity guanyl-nucleotide exchange factor activity	developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development renal system process system process localization import into cell developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development renal system process system process localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport protein localization establishment of protein localization cellular localization nitrogen compound transport intracellular protein transmembrane transport intracellular transport transmembrane transport protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization establishment of localization in cell intracellular protein transport regulation of vascular permeability circulatory system process biological regulation vascular process in circulatory system regulation of biological quality blood circulation negative regulation of tissue remodeling regulation of biological process regulation of developmental process negative regulation of developmental process negative regulation of biological process regulation of tissue remodeling regulation of blood vessel remodeling anatomical structure morphogenesis blood vessel remodeling negative regulation of blood vessel remodeling tissue remodeling regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of biological process cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction regulation of signal transduction regulation of Rho protein signal transduction intracellular signal transduction Rho protein signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling cellular metabolic process negative regulation of metabolic process reactive oxygen species metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process metabolic process regulation of metabolic process regulation of reactive oxygen species metabolic process protein phosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process focal adhesion assembly cell-substrate junction assembly cell-substrate adhesion cellular component biogenesis cell adhesion cell junction organization cellular component assembly cell-matrix adhesion cell junction assembly cell-substrate junction organization definitive hemopoiesis cellular developmental process hemopoiesis cell differentiation cell development regulation of immune effector process neutrophil activation regulation of myeloid leukocyte mediated immunity regulated exocytosis negative regulation of transport cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity myeloid leukocyte activation neutrophil activation involved in immune response negative regulation of secretion leukocyte mediated immunity regulation of immune system process negative regulation of secretion by cell negative regulation of myeloid leukocyte mediated immunity immune response negative regulation of immune response negative regulation of immune effector process immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis regulation of immune response negative regulation of neutrophil degranulation negative regulation of regulated secretory pathway negative regulation of leukocyte degranulation leukocyte activation regulation of regulated secretory pathway neutrophil mediated immunity secretion by cell regulation of secretion by cell negative regulation of exocytosis regulation of neutrophil degranulation leukocyte activation involved in immune response neutrophil degranulation regulation of leukocyte degranulation secretion negative regulation of response to stimulus cell activation export from cell myeloid cell activation involved in immune response negative regulation of immune system process immune system process regulation of exocytosis negative regulation of leukocyte mediated immunity granulocyte activation epithelium development epidermal cell differentiation epidermis development tissue development epithelial cell differentiation skin development keratinocyte differentiation multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells ear morphogenesis embryonic organ morphogenesis ear development sensory organ development embryonic morphogenesis embryo development sensory organ morphogenesis inner ear development inner ear morphogenesis animal organ morphogenesis embryonic organ development regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin nervous system process neuromuscular process neuromuscular process controlling balance respiratory burst regulation of respiratory burst negative regulation of respiratory burst negative regulation of locomotion regulation of cell motility negative regulation of cellular extravasation regulation of cell migration cellular extravasation cell migration cell motility negative regulation of cell migration locomotion regulation of leukocyte migration leukocyte migration negative regulation of leukocyte migration regulation of locomotion negative regulation of cell motility regulation of cellular extravasation mononuclear cell migration myeloid leukocyte migration macrophage migration activation of GTPase activity positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity cell cycle regulation of cell cycle negative regulation of mononuclear cell migration regulation of macrophage migration regulation of mononuclear cell migration negative regulation of macrophage migration	membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse neuron spine neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse dendrite dendritic tree axon cell periphery plasma membrane protein-containing complex postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000219	Dbl homology (DH) domain	Domain
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR037769	Abr/Bcr	Family
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR036481	Bcr-Abl oncoprotein oligomerisation domain superfamily	Homologous Superfamily
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000008	C2 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR015123	Bcr-Abl oncoprotein oligomerisation	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P11274	chronic myelogenous leukemia, BCR-ABL1 positive chromosome 22q11.2 deletion syndrome, distal blast phase chronic myelogenous leukemia, BCR-ABL1 positive Neoplasms, Experimental bone marrow neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis acute T cell leukemia bladder transitional cell carcinoma Burkitt lymphoma leukemia myeloproliferative neoplasm osteosarcoma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor chronic myelogenous leukemia, BCR-ABL1 positive chromosome 22q11.2 deletion syndrome, distal blast phase chronic myelogenous leukemia, BCR-ABL1 positive Neoplasms, Experimental bone marrow neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis acute T cell leukemia bladder transitional cell carcinoma Burkitt lymphoma leukemia myeloproliferative neoplasm osteosarcoma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor cancer leukemia, acute lymphocytic, susceptibility to, 1 major depressive disorder ovarian cancer bipolar disorder childhood acute lymphoblastic leukemia large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.