Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042523 3000503 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042528 3000503 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042531 3000526 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042533 3000526 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042531 3000526 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042533 3000526 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042528 3000503 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042523 3000503 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042523 3000503 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042529 3000503 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042535 3000769 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042525 3000503 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042533 3000526 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB TolC docking domain (DN and DC subdomains) 8042531 3000526 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB transmembrane domain 8042534 3000769 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyMultidrug efflux transporter AcrB pore domain PN1, PN2, PC1 and PC2 subdomains 8042528 3000503 SCOP2B (2022-06-29)
FSCOP2 FamilyAcrZ-like 8075668 4004543 SCOP2 (2022-06-29)
FSCOP2 SuperfamilyAcrZ-like 8090988 3002474 SCOP2 (2022-06-29)
GSCOP2B SuperfamilyAcrZ-like 8090988 3002474 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyAcrZ-like 8090988 3002474 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AACR_tran_4the5nc5A1 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
AACR_tran_1ste5nc5A4 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
AACR_tran_5the5nc5A8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
AACR_tran_3rde5nc5A3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
AACR_tran_6the5nc5A2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
AACR_tran_2nde5nc5A7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
AACR_tran_6th_1e5nc5A5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
BACR_tran_4the5nc5B5 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
BACR_tran_1ste5nc5B8 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
BACR_tran_5the5nc5B1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
BACR_tran_3rde5nc5B7 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
BACR_tran_6the5nc5B6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
BACR_tran_2nde5nc5B2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
BACR_tran_6th_1e5nc5B3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
CACR_tran_4the5nc5C7 A: alpha bundlesX: Multidrug efflux transporter AcrB transmembrane domain (From Topology)H: Multidrug efflux transporter AcrB transmembrane domain (From Topology)T: Multidrug efflux transporter AcrB transmembrane domainF: ACR_tran_4thECOD (1.6)
CACR_tran_1ste5nc5C4 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_1stECOD (1.6)
CACR_tran_5the5nc5C3 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_5thECOD (1.6)
CACR_tran_3rde5nc5C6 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_3rdECOD (1.6)
CACR_tran_6the5nc5C2 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB pore domainF: ACR_tran_6thECOD (1.6)
CACR_tran_2nde5nc5C1 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_2ndECOD (1.6)
CACR_tran_6th_1e5nc5C5 A: a+b two layersX: Alpha-beta plaitsH: Ferredoxin domains in multidrug efflux transporterT: Multidrug efflux transporter AcrB TolC docking domainF: ACR_tran_6th_1ECOD (1.6)
DAnk_2e5nc5D1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Ankyrin repeat (From Topology)T: Ankyrin repeatF: Ank_2ECOD (1.6)
EAnk_2e5nc5E1 A: alpha superhelicesX: Repetitive alpha hairpinsH: Ankyrin repeat (From Topology)T: Ankyrin repeatF: Ank_2ECOD (1.6)
FAcrZe5nc5F1 A: extended segmentsX: Multidrug efflux pump accessory protein AcrZ (From Topology)H: Multidrug efflux pump accessory protein AcrZ (From Topology)T: Multidrug efflux pump accessory protein AcrZF: AcrZECOD (1.6)
GAcrZe5nc5G1 A: extended segmentsX: Multidrug efflux pump accessory protein AcrZ (From Topology)H: Multidrug efflux pump accessory protein AcrZ (From Topology)T: Multidrug efflux pump accessory protein AcrZF: AcrZECOD (1.6)
HAcrZe5nc5H1 A: extended segmentsX: Multidrug efflux pump accessory protein AcrZ (From Topology)H: Multidrug efflux pump accessory protein AcrZ (From Topology)T: Multidrug efflux pump accessory protein AcrZF: AcrZECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
A3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
A3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
A3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
A3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
B1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
B3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
B3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
B3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
B3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
C1.20.1640.10 Mainly Alpha Up-down Bundle Multidrug efflux transporter AcrB transmembrane fold Multidrug efflux transporter AcrB transmembrane domainCATH (4.3.0)
C3.30.70.1430 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
C3.30.70.1320 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domain likeCATH (4.3.0)
C3.30.2090.10 Alpha Beta 2-Layer Sandwich Multidrug efflux transporter AcrB TolC docking domain DN and DC subdomainsCATH (4.3.0)
C3.30.70.1440 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Multidrug efflux transporter AcrB pore domainCATH (4.3.0)
D1.25.40.20 Mainly Alpha Alpha Horseshoe Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat Ankyrin repeat-containing domainCATH (4.3.0)
E1.25.40.20 Mainly Alpha Alpha Horseshoe Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat Ankyrin repeat-containing domainCATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C
ARO:3000216acrBProtein subunit of AcrA-AcrB-TolC multidrug efflux complex. AcrB functions as a herterotrimer which forms the inner membrane component and is primarily responsible for substrate recognition and energy transduction by acting as a drug/proton antiporter.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C
ARO:0010004resistance-nodulation-cell division (RND) antibiotic efflux pumpfluoroquinolone antibiotic, cephalosporin, glycylcycline, penam, tetracycline antibiotic, rifamycin antibiotic, phenicol antibiotic, disinfecting agents and antisepticsantibiotic effluxCARD (3.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C
PF00873AcrB/AcrD/AcrF family (ACR_tran)AcrB/AcrD/AcrF family- Family
F, G, H
PF10766Multidrug efflux pump-associated protein AcrZ (AcrZ)Multidrug efflux pump-associated protein AcrZ- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C
Multidrug efflux pump subunit AcrB
D, E
DARPin---
F, G, H
Multidrug efflux pump accessory protein AcrZ

Membrane Protein Annotation: OPM OPM Database Homepage

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
A, B, C, F, G
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

ChainsExternal LinkComment
A, B, C, F, G
MemProtMDAnnotated as membrane protein by MemProtMD