5NMI

Cytochrome bc1 bound to the inhibitor MJM170

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038264	3000966	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8038265	3000517	SCOP2B (2022-06-29)
N [auth P]	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038264	3000966	SCOP2B (2022-06-29)
N [auth P]	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8038265	3000517	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038259	3001831	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038258	3001831	SCOP2B (2022-06-29)
L [auth N]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038259	3001831	SCOP2B (2022-06-29)
L [auth N]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038258	3001831	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038260	3001831	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038263	3001831	SCOP2B (2022-06-29)
M [auth O]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038260	3001831	SCOP2B (2022-06-29)
M [auth O]	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8038263	3001831	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	8038268	3000762	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Cytochrome c	8038266	3000815	SCOP2B (2022-06-29)
O [auth Q]	SCOP2B Superfamily	Cytochrome c	8038266	3000815	SCOP2B (2022-06-29)
O [auth Q]	SCOP2B Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	8038268	3000762	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ISP domain	8038267	3000233	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ISP transmembrane anchor	8038269	3000753	SCOP2B (2022-06-29)
P [auth R]	SCOP2B Superfamily	ISP transmembrane anchor	8038269	3000753	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038272	3000797	SCOP2B (2022-06-29)
Q [auth S]	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038272	3000797	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038274	3000770	SCOP2B (2022-06-29)
R [auth T]	SCOP2B Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038274	3000770	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038275	3000806	SCOP2B (2022-06-29)
S [auth U]	SCOP2B Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8038275	3000806	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8037844	3000779	SCOP2B (2022-06-29)
U [auth W]	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8037844	3000779	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Cytochrom_B_C	e5nmiC1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
C	Cytochrome_B	e5nmiC2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
N [auth P]	Cytochrom_B_C	e5nmiP1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
N [auth P]	Cytochrome_B	e5nmiP2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
A	Peptidase_M16_C	e5nmiA1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
A	Peptidase_M16	e5nmiA2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
L [auth N]	Peptidase_M16_C	e5nmiN1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
L [auth N]	Peptidase_M16	e5nmiN2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
K	UCR_6-4kD	e5nmiK1	A: extended segments	X: Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_6-4kD	ECOD (1.6)
V [auth X]	UCR_6-4kD	e5nmiX1	A: extended segments	X: Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_6-4kD	ECOD (1.6)
B	Peptidase_M16_C	e5nmiB1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
B	Peptidase_M16	e5nmiB2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
M [auth O]	Peptidase_M16_C	e5nmiO2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
M [auth O]	Peptidase_M16	e5nmiO1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
D	Cytochrom_C1_N	e5nmiD1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
D	Cytochrom_C1_C	e5nmiD2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
O [auth Q]	Cytochrom_C1_N	e5nmiQ1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
O [auth Q]	Cytochrom_C1_C	e5nmiQ2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
E	Rieske_cytochrome_bc1,Rieske_6	e5nmiE2	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1,Rieske_6	ECOD (1.6)
E	UCR_TM	e5nmiE1	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
I	Ubiq-Cytc-red_N	e5nmiI1	A: extended segments	X: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	H: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	T: Ubiquinol-cytochrome c reductase 8 kDa protein	F: Ubiq-Cytc-red_N	ECOD (1.6)
P [auth R]	UCR_TM	e5nmiR1	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
T [auth V]	Ubiq-Cytc-red_N	e5nmiV1	A: extended segments	X: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	H: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	T: Ubiquinol-cytochrome c reductase 8 kDa protein	F: Ubiq-Cytc-red_N	ECOD (1.6)
F	UCR_14kD	e5nmiF1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)
Q [auth S]	UCR_14kD	e5nmiS1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)
G	UcrQ	e5nmiG1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
R [auth T]	UcrQ	e5nmiT1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
H	UCR_hinge	e5nmiH1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
S [auth U]	UCR_hinge	e5nmiU1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
J	UCR_UQCRX_QCR9	e5nmiJ1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
U [auth W]	UCR_UQCRX_QCR9	e5nmiW1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
N [auth P]	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
A	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
L [auth N]	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
B	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
M [auth O]	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
D	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
D	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
O [auth Q]	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
O [auth Q]	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
E	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
E	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
P [auth R]	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
F	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)
Q [auth S]	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)
G	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)
R [auth T]	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)
H	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)
S [auth U]	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)
J	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)
U [auth W]	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, N [auth P]	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
C, N [auth P]	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
A, L [auth N]	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
A, L [auth N]	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
K, V [auth X]	PF08997	Ubiquinol-cytochrome C reductase complex, 6.4kD protein (UCR_6-4kD)	Ubiquinol-cytochrome C reductase complex, 6.4kD protein	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is an essential component of the mitochondrial cellular respiratory chain. This family represents the 6.4kD protein, which may be closely linked to the iron-sulphur protein in the ...	The ubiquinol-cytochrome C reductase complex (cytochrome bc1 complex) is an essential component of the mitochondrial cellular respiratory chain. This family represents the 6.4kD protein, which may be closely linked to the iron-sulphur protein in the complex and function as an iron-sulphur protein binding factor [1].	Domain
B, M [auth O]	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
B, M [auth O]	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
D, O [auth Q]	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family
E, I, P [auth R], T [auth V]	PF02921	Ubiquinol cytochrome reductase transmembrane region (UCR_TM)	Ubiquinol cytochrome reductase transmembrane region	-	Family
E, I, P [auth R], T [auth V]	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
G, R [auth T]	PF02939	UcrQ family (UcrQ)	UcrQ family	-	Family
H, S [auth U]	PF02320	Ubiquinol-cytochrome C reductase hinge protein (UCR_hinge)	Ubiquinol-cytochrome C reductase hinge protein	-	Family
J, U [auth W]	PF05365	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like (UCR_UQCRX_QCR9)	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, N [auth P]	Cytochrome b	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding quinone binding ubiquinone binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane protein complex transporter complex respiratory chain complex III transmembrane transporter complex oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane
A, L [auth N]	Cytochrome b-c1 complex subunit 1, mitochondrial	cation binding ion binding binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
K, V [auth X]	ARG-ASN-TRP-VAL-PRO-THR-ALA-GLN-LEU-TRP-GLY-ALA-VAL-GLY-ALA-VAL-GLY-LEU-VAL-SER-ALA-THR	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane
B, M [auth O]	Cytochrome b-c1 complex subunit 2, mitochondrial	cation binding ion binding binding metal ion binding small molecule binding peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity	proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
D, O [auth Q]	Cytochrome c1, heme protein, mitochondrial	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
E, I, P [auth R], T [auth V]	Cytochrome b-c1 complex subunit Rieske, mitochondrial	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
F, Q [auth S]	Cytochrome b-c1 complex subunit 7	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	-
G, R [auth T]	Cytochrome b-c1 complex subunit 8	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	-
H, S [auth U]	Cytochrome b-c1 complex subunit 6, mitochondrial	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	-
J, U [auth W]	Cytochrome b-c1 complex subunit 9	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, N [auth P]	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
C, N [auth P]	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
C, N [auth P]	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
C, N [auth P]	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
C, N [auth P]	IPR005798	Cytochrome b/b6, C-terminal	Domain
C, N [auth P]	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
C, N [auth P]	IPR030689	Cytochrome b	Family
C, N [auth P]	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
A, L [auth N]	IPR007863	Peptidase M16, C-terminal	Domain
A, L [auth N]	IPR011765	Peptidase M16, N-terminal	Domain
A, L [auth N]	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
A, L [auth N]	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Family
K, V [auth X]	IPR029027	Single alpha-helix domain superfamily	Homologous Superfamily
K, V [auth X]	IPR015089	Cytochrome b-c1 complex subunit 10	Family
B, M [auth O]	IPR007863	Peptidase M16, C-terminal	Domain
B, M [auth O]	IPR011765	Peptidase M16, N-terminal	Domain
B, M [auth O]	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
B, M [auth O]	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Family
B, M [auth O]	IPR001431	Peptidase M16, zinc-binding site	Binding Site
D, O [auth Q]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
D, O [auth Q]	IPR002326	Cytochrome c1	Family
D, O [auth Q]	IPR009056	Cytochrome c-like domain	Domain
D, O [auth Q]	IPR021157	Cytochrome c1, transmembrane anchor, C-terminal	Homologous Superfamily
E, I, P [auth R], T [auth V]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
E, I, P [auth R], T [auth V]	IPR014349	Rieske iron-sulphur protein	Family
E, I, P [auth R], T [auth V]	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
E, I, P [auth R], T [auth V]	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
E, I, P [auth R], T [auth V]	IPR015248	Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal	Domain
E, I, P [auth R], T [auth V]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
E, I, P [auth R], T [auth V]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
E, I, P [auth R], T [auth V]	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
E, I, P [auth R], T [auth V]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
F, Q [auth S]	IPR003197	Cytochrome b-c1 complex subunit 7	Family
F, Q [auth S]	IPR036544	Cytochrome b-c1 complex subunit 7 superfamily	Homologous Superfamily
G, R [auth T]	IPR004205	Cytochrome b-c1 complex subunit 8	Family
G, R [auth T]	IPR036642	Cytochrome b-c1 complex subunit 8 superfamily	Homologous Superfamily
H, S [auth U]	IPR003422	Cytochrome b-c1 complex, subunit 6	Family
H, S [auth U]	IPR023184	Ubiquinol-cytochrome C reductase hinge domain	Domain
H, S [auth U]	IPR036811	Ubiquinol-cytochrome C reductase hinge domain superfamily	Homologous Superfamily
J, U [auth W]	IPR008027	Cytochrome b-c1 complex subunit 9	Family
J, U [auth W]	IPR036656	Cytochrome b-c1 complex subunit 9 superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L [auth N], M [auth O], N [auth P], O [auth Q], P [auth R], Q [auth S], R [auth T], S [auth U], T [auth V], U [auth W], V [auth X]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex III (bc1 and b6f) superfamily	Cytochrome bc1 and b6f complexes

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L [auth N], M [auth O], N [auth P], O [auth Q], P [auth R], Q [auth S], R [auth T], S [auth U], T [auth V], U [auth W], V [auth X]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L [auth N], M [auth O], N [auth P], O [auth Q], P [auth R], Q [auth S], R [auth T], S [auth U], T [auth V], U [auth W], V [auth X]	MemProtMD	Annotated as membrane protein by MemProtMD