Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APBP_dimere5oizA2 A: beta complex topologyX: Penicillin binding protein dimerisation domain (From Topology)H: Penicillin binding protein dimerisation domain (From Topology)T: Penicillin binding protein dimerisation domainF: PBP_dimerECOD (1.6)
ATranspeptidase_1st_1e5oizA4 A: alpha complex topologyX: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)H: alpha-helical domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: alpha-helical domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_1st_1ECOD (1.6)
APASTA_2e5oizA5 A: a+b two layersX: CI-2 family of serine protease inhibitors-likeH: Penicillin-binding protein 2x (pbp-2x)-C (From Topology)T: Penicillin-binding protein 2x (pbp-2x)-CF: PASTA_2ECOD (1.6)
APASTA_1e5oizA3 A: a+b two layersX: CI-2 family of serine protease inhibitors-likeH: Penicillin-binding protein 2x (pbp-2x)-C (From Topology)T: Penicillin-binding protein 2x (pbp-2x)-CF: PASTA_1ECOD (1.6)
APBP_2x_ClpSe5oizA6 A: a+b two layersX: ClpS-likeH: Penicillin binding protein ClpS-like domain (From Topology)T: Penicillin binding protein ClpS-like domainF: PBP_2x_ClpSECOD (1.6)
ATranspeptidase_2nde5oizA1 A: a+b three layersX: Profilin-likeH: a+b domain in beta-lactamase/transpeptidase-like proteins (From Topology)T: a+b domain in beta-lactamase/transpeptidase-like proteinsF: Transpeptidase_2ndECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF03717Penicillin-binding Protein dimerisation domain (PBP_dimer)Penicillin-binding Protein dimerisation domainThis domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' st ...This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure.
Domain
PF00905Penicillin binding protein transpeptidase domain (Transpeptidase)Penicillin binding protein transpeptidase domainThe active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.Domain
PF03793PASTA domain (PASTA)PASTA domainThis domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases [1]. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a smal ...This domain is found at the C termini of several Penicillin-binding proteins and bacterial serine/threonine kinases [1]. It binds the beta-lactam stem, which implicates it in sensing D-alanyl-D-alanine - the PBP transpeptidase substrate. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and Serine/Threonine kinase Associated domain.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Penicillin-binding protein 2X