5R5Y

PanDDA analysis group deposition -- Crystal Structure of FIBRINOGEN-LIKE GLOBE DOMAIN OF HUMAN TENASCIN-C in complex with Z509756472

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5r5ya1	Alpha and beta proteins (a+b)	Fibrinogen C-terminal domain-like	Fibrinogen C-terminal domain-like	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5r5ya2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fibrinogen_C	e5r5yA1	A: a+b complex topology	X: Fibrinogen C-terminal domain-like (From Topology)	H: Fibrinogen C-terminal domain-like (From Topology)	T: Fibrinogen C-terminal domain-like	F: Fibrinogen_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00147	Fibrinogen beta and gamma chains, C-terminal globular domain (Fibrinogen_C)	Fibrinogen beta and gamma chains, C-terminal globular domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Tenascin C (Hexabrachion), isoform CRA_a	protein binding binding syndecan binding proteoglycan binding carbohydrate derivative binding cell adhesion molecule binding protein-containing complex binding integrin binding signaling receptor binding structural molecule activity extracellular matrix structural constituent	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation developmental growth branching morphogenesis of an epithelial tube developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation developmental growth branching morphogenesis of an epithelial tube respiratory tube development multicellular organism development tube morphogenesis anatomical structure development lung morphogenesis lung development respiratory system development animal organ morphogenesis epithelial tube morphogenesis system development epithelium development axis elongation tube development branch elongation of an epithelium animal organ development growth morphogenesis of an epithelium tissue development developmental growth involved in morphogenesis tissue morphogenesis anatomical structure morphogenesis morphogenesis of a branching structure bud outgrowth involved in lung branching epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium cellular response to stimulus response to stimulus cell projection organization cell development neuron projection development regeneration response to axon injury neuron projection regeneration cellular component organization neurogenesis axon regeneration neuron differentiation cellular response to stress response to stress cellular component organization or biogenesis response to wounding peripheral nervous system axon regeneration plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development odontogenesis of dentin-containing tooth odontogenesis cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cell junction organization neuromuscular junction development synapse organization regulation of growth regulation of cellular component organization regulation of cell growth cell growth response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid response to chemical cellular response to lipid regulation of cell motility regulation of locomotion regulation of cell migration cell migration cell motility locomotion response to nutrient levels response to nutrient cellular response to organic cyclic compound response to vitamin cellular response to vitamin D cellular response to nutrient levels response to vitamin D cellular response to vitamin cellular response to nutrient response to organic cyclic compound response to alcohol response to ethanol cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to mechanical stimulus response to abiotic stimulus response to external stimulus regulation of defense response regulation of response to external stimulus defense response regulation of inflammatory response regulation of response to stimulus regulation of response to stress inflammatory response response to ketone response to prostaglandin cellular response to prostaglandin D stimulus response to endogenous stimulus cellular response to prostaglandin stimulus cellular response to endogenous stimulus cellular response to alcohol response to hormone response to prostaglandin D cellular response to ketone cellular response to hormone stimulus reproductive system development prostate gland development reproductive process gland development urogenital system development developmental process involved in reproduction prostate gland epithelium morphogenesis prostate gland morphogenesis gland morphogenesis reproductive structure development mesenchymal-epithelial cell signaling signaling mesenchymal-epithelial cell signaling involved in prostate gland development cell-cell signaling cell communication response to fibroblast growth factor response to growth factor negative regulation of cellular process negative regulation of biological process negative regulation of cell adhesion	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix protein-containing complex protein complex involved in cell-matrix adhesion tenascin complex anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix protein-containing complex protein complex involved in cell-matrix adhesion tenascin complex protein complex involved in cell adhesion interstitial matrix membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region extracellular space perisynaptic extracellular matrix synapse-associated extracellular matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013111	EGF-like domain, extracellular	Domain
A	IPR041161	Tenascin, EGF-like domain	Domain
A	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1	Homologous Superfamily
A	IPR000742	EGF-like domain	Domain
A	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain	Domain
A	IPR003961	Fibronectin type III	Domain
A	IPR050991	Extracellular Matrix Regulatory Proteins	Family
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR036056	Fibrinogen-like, C-terminal	Homologous Superfamily
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P24821	autosomal dominant nonsyndromic deafness 56 asthma endometriosis melanoma nonsyndromic genetic deafness varicose disease pleural disease Lung Injury juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma myopathy allergic rhinitis oligodendroglioma autosomal dominant nonsyndromic deafness 56 asthma endometriosis melanoma nonsyndromic genetic deafness varicose disease pleural disease Lung Injury juvenile dermatomyositis lung cancer malignant colon neoplasm malignant mesothelioma myopathy allergic rhinitis oligodendroglioma atopic eczema osteosarcoma Becker muscular dystrophy pilocytic astrocytoma congestive heart failure Sjogren syndrome Duchenne muscular dystrophy interstitial cystitis limb-girdle muscular dystrophy lung carcinoma malignant ependymoma medulloblastoma non-small cell lung carcinoma osteoarthritis autosomal dominant nonsyndromic deafness 1 ovarian cancer breast cancer cutaneous melanoma subependymal giant cell astrocytoma ductal breast carcinoma in situ interstitial lung disease lung adenocarcinoma malignant glioma astrocytic tumor osteoarthritis, hip pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cystic fibrosis ulcerative colitis Emery-Dreifuss muscular dystrophy glioblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.