Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BF_UNCLASSIFIEDe5rlhB2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: F_UNCLASSIFIEDECOD (1.6)
BF_UNCLASSIFIEDe5rlhB3 A: alpha bundlesX: MERS-CoV helicase helical bundle domain (From Topology)H: MERS-CoV helicase helical bundle domain (From Topology)T: MERS-CoV helicase helical bundle domainF: F_UNCLASSIFIEDECOD (1.6)
BAAA_12e5rlhB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: AAA_12ECOD (1.6)
BAAA_11e5rlhB4 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: AAA_11ECOD (1.6)
BF_UNCLASSIFIEDe5rlhB5 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: RING/U-boxF: F_UNCLASSIFIEDECOD (1.6)
AF_UNCLASSIFIEDe5rlhA2 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: F_UNCLASSIFIEDECOD (1.6)
AF_UNCLASSIFIEDe5rlhA4 A: alpha bundlesX: MERS-CoV helicase helical bundle domain (From Topology)H: MERS-CoV helicase helical bundle domain (From Topology)T: MERS-CoV helicase helical bundle domainF: F_UNCLASSIFIEDECOD (1.6)
AAAA_12e5rlhA6 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: AAA_12ECOD (1.6)
AAAA_11e5rlhA5 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: AAA_11ECOD (1.6)
AF_UNCLASSIFIEDe5rlhA1 A: few secondary structure elementsX: RING/U-box-likeH: RING/U-box-likeT: RING/U-boxF: F_UNCLASSIFIEDECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF13087AAA domain (AAA_12)AAA domainThis family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.Domain
A, B
PF20631Coronavirus Nonstructural protein 13, 1B domain (CoV_NSP13_1B)Coronavirus Nonstructural protein 13, 1B domainHelicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the unwinding of duplex oligonucleotides into single strands in an ...Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the unwinding of duplex oligonucleotides into single strands in an NTP-dependent manner. It is a multidomain protein consisting of a N-terminal zinc-binding domain (ZBD), a stalk domain that connects the ZBD with the 1B domain and the helicase domain (that contains two RecA1 and RecA2 domains). ZBD, stalk and 1B domains are unique to nidovirus helicases [1]. NSP13 adopts a triangular pyramid shape in which the two RecA1 and A2 and 1B domains form the triangular base while N-terminal ZBD and stalk domains are arranged at the apex of the pyramid [1,2]. Recently, it has been reported that SARS-CoV-2 NSP13 as an interferon antagonist [3]. This is 1B domain of NSP13 [1], which has a regulatory role modulating the nucleic acid substrate binding [2].
Domain
A, B
PF20632Coronavirus Non-structural protein 13, zinc-binding domain (CoV_NSP13_ZBD)Coronavirus Non-structural protein 13, zinc-binding domainHelicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the unwinding of duplex oligonucleotides into single strands in an ...Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the unwinding of duplex oligonucleotides into single strands in an NTP-dependent manner. It In SARS-CoV, it has been shown that NSP12 directly interacts with NSP13 and enhances its helicase activity. It is a multidomain protein consisting of a N-terminal zinc-binding domain (ZBD), a stalk domain that connects the ZBD with the 1B domain and the helicase domain (that contains two RecA1 and RecA2 domains). ZBD, stalk and 1B domains are unique to nidovirus helicases [1]. NSP13 adopts a triangular pyramid shape in which the two RecA1 and A2 and 1B domains form the triangular base while N-terminal ZBD and stalk domains are arranged at the apex of the pyramid [1,2]. Recently, it has been reported that SARS-CoV-2 NSP13 as an interferon antagonist [3]. This is the zinc-binding domain (ZBD) found at the N-terminal of NSP13 which is critically involved in nidovirus replication and transcription, modulating the ATPase/helicase activity in cis [1,2]. It includes conserved cysteines and histidines involved in three zinc-binding sites [4].
Domain
A, B
PF20633Coronavirus Nonstructural protein 13, stalk domain (CoV_NSP13_stalk)Coronavirus Nonstructural protein 13, stalk domainHelicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the unwinding of duplex oligonucleotides into single strands in a N ...Helicase nonstructural protein 13 (NSP13) is encoded by the replicase polyprotein 1a/ab of coronaviruses and released after a proteolytic process. It plays a critical role catalysing the unwinding of duplex oligonucleotides into single strands in a NTP-dependent manner. It is a multidomain protein consisting of a N-terminal zinc-binding domain (ZBD), a stalk domain that connects the ZBD with the 1B domain and the helicase domain (that contains two RecA1 and RecA2 domains). The ZBD, stalk and 1B domains are unique to nidovirus helicases [1]. NSP13 adopts a triangular pyramid shape in which the two RecA1 and A2 and 1B domains form the triangular base while N-terminal ZBD and stalk domains are arranged at the apex of the pyramid [1,2]. Recently, it has been reported that SARS-CoV-2 NSP13 as an interferon antagonist [3]. This is the stalk domain.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Helicase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
A, B
IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
A, B
IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
A, B
IPR044315Nonstructural protein 14, betacoronavirusDomain
A, B
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A, B
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A, B
IPR046441RNA-dependent RNA polymerase, coronavirusDomain
A, B
IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
A, B
IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
A, B
IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
A, B
IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
A, B
IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
A, B
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B
IPR013016Peptidase C16, coronavirusDomain
A, B
IPR009466Non-structural protein 14, coronavirusDomain
A, B
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A, B
IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
A, B
IPR047570NSP12, interface domain, coronavirusDomain
A, B
IPR018995RNA synthesis protein NSP10, coronavirusDomain
A, B
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A, B
IPR050534Coronaviruses polyprotein 1abFamily
A, B
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
A, B
IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
A, B
IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
A, B
IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
A, B
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
A, B
IPR014828Non-structural protein NSP7, coronavirusDomain
A, B
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
A, B
IPR014829Non-structural protein NSP8, coronavirusDomain
A, B
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A, B
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, B
IPR044389Non-structural protein 2, SARS-CoV-likeDomain
A, B
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, B
IPR008740Peptidase C30, coronavirusDomain
A, B
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A, B
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A, B
IPR049894Coronavirus NSP3, 3Ecto domainDomain
A, B
IPR043472Macro domain-likeHomologous Superfamily
A, B
IPR043609NendoU domain, nidovirusDomain
A, B
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
A, B
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A, B
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
A, B
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A, B
IPR044351RNA-dependent RNA polymerase, SARS-CoV-likeDomain
A, B
IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
A, B
IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
A, B
IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
A, B
IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
A, B
IPR043611Coronavirus replicase NSP3, C-terminalDomain
A, B
IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
A, B
IPR047566Coronavirus replicase NSP3, Y domainDomain
A, B
IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
A, B
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A, B
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B
IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
A, B
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A, B
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A, B
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A, B
IPR043610Non-structural protein 6, coronavirusDomain
A, B
IPR027351(+) RNA virus helicase core domainDomain
A, B
IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
A, B
IPR009461Non-structural protein NSP16, coronavirus-likeDomain
A, B
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A, B
IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
A, B
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
A, B
IPR044401NSP15, NendoU domain, coronavirusDomain
A, B
IPR014822Non-structural protein NSP9, coronavirusDomain
A, B
IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR021590NSP1, globular domain, betacoronavirusDomain
A, B
IPR044367Non-structural protein 6, betacoronavirusDomain
A, B
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A, B
IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
A, B
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A, B
IPR046438Nidovirus 2-O-methyltransferaseDomain
A, B
IPR002589Macro domainDomain
A, B
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
A, B
IPR044371Non-structural protein 3, X-domain-likeDomain
A, B
IPR007094RNA-directed RNA polymerase, catalytic domainDomain