5RXA

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z2856434829

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e5rxaA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: C2 domain (From Topology)	T: C2 domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	Exo_endo_phos	e5rxaA2	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF22669	Endonuclease/Exonuclease/phosphatase family 2 (Exo_endo_phos2)	Endonuclease/Exonuclease/phosphatase family 2	This large family of proteins includes a number of nucleases and phosphatases such as DNAase I, Exonuclease III and Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity SH3 domain binding protein binding binding protein domain specific binding inositol-1,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity SH3 domain binding protein binding binding protein domain specific binding inositol-1,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol trisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol phosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate phosphatase activity phosphatidylinositol bisphosphate phosphatase activity phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity inositol tetrakisphosphate phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus negative regulation of cellular process regulation of cell communication cellular process signal transduction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity immune response immune system process B cell mediated immunity leukocyte mediated immunity immunoglobulin mediated immune response adaptive immune response immune effector process negative regulation of lymphocyte proliferation multicellular organismal process regulation of leukocyte activation regulation of cell activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte activation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation regulation of multicellular organismal process regulation of immune system process negative regulation of B cell activation regulation of lymphocyte proliferation regulation of leukocyte proliferation negative regulation of cell population proliferation cell population proliferation B cell activation cell activation B cell proliferation negative regulation of B cell proliferation negative regulation of cell activation negative regulation of immune system process regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation immune response-regulating cell surface receptor signaling pathway positive regulation of biological process positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway T cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response phosphatidylinositol metabolic process dephosphorylation glycerophospholipid metabolic process lipid modification primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation phosphate-containing compound metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process interleukin-6 production regulation of interleukin-6 production regulation of cytokine production cytokine production negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of interleukin-6 production negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process negative regulation of immune response apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process positive regulation of cellular process myeloid leukocyte differentiation regulation of leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation multicellular organism development cell differentiation osteoclast differentiation anatomical structure development negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation regulation of hemopoiesis leukocyte differentiation glycerophospholipid biosynthetic process lipid biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process determination of adult lifespan negative regulation of tissue remodeling homeostatic process negative regulation of bone remodeling regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption negative regulation of bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis positive regulation of developmental process positive regulation of cell differentiation myeloid cell homeostasis erythrocyte homeostasis erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation positive regulation of myeloid cell differentiation homeostasis of number of cells regulation of granulocyte differentiation regulation of neutrophil differentiation negative regulation of neutrophil differentiation negative regulation of granulocyte differentiation granulocyte differentiation neutrophil differentiation intracellular signal transduction mononuclear cell differentiation positive regulation of B cell differentiation lymphocyte differentiation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of cell development positive regulation of multicellular organismal process positive regulation of lymphocyte activation regulation of B cell differentiation B cell differentiation positive regulation of hemopoiesis regulation of lymphocyte differentiation positive regulation of B cell activation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation monocyte differentiation negative regulation of monocyte differentiation regulation of monocyte differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane microdomain membrane raft intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036860	SH2 domain superfamily	Homologous Superfamily
A	IPR000980	SH2 domain	Domain
A	IPR000300	Inositol polyphosphate-related phosphatase	Domain
A	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q92835	ulcerative colitis Liver Cirrhosis, Experimental Crohn disease acute myeloid leukemia astrocytic tumor cutaneous lupus erythematosus interstitial cystitis lymphoplasmacytic lymphoma medulloblastoma rheumatoid arthritis allergic rhinitis atopic eczema gastric carcinoma invasive ductal breast carcinoma lung cancer ulcerative colitis Liver Cirrhosis, Experimental Crohn disease acute myeloid leukemia astrocytic tumor cutaneous lupus erythematosus interstitial cystitis lymphoplasmacytic lymphoma medulloblastoma rheumatoid arthritis allergic rhinitis atopic eczema gastric carcinoma invasive ductal breast carcinoma lung cancer malignant colon neoplasm osteosarcoma subependymal giant cell astrocytoma Alzheimer disease inflammatory bowel disease ischemia reperfusion injury lung carcinoma malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.