Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyEndoU-like 8092437 3000687 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8092436 3000118 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyS-adenosyl-L-methionine-dependent methyltransferases 8092436 3000118 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyEndoU-like 8092437 3000687 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AXendoU_likee5sadA2 A: a+b complex topologyX: RNase A-likeH: EndoU-like (From Topology)T: EndoU-likeF: XendoU_likeECOD (1.6)
ANSP11_2nde5sadA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: NSP11_2ndECOD (1.6)
BXendoU_likee5sadB1 A: a+b complex topologyX: RNase A-likeH: EndoU-like (From Topology)T: EndoU-likeF: XendoU_likeECOD (1.6)
BNSP11_2nde5sadB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: NSP11_2ndECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF19215Coronavirus replicase NSP15, uridylate-specific endoribonuclease (CoV_NSP15_C)Coronavirus replicase NSP15, uridylate-specific endoribonucleaseThis entry represents the C-terminal domain of coronavirus non-structural protein 15 (NSP15 or nsp15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain exhibits endoribonuclease activity designated ...This entry represents the C-terminal domain of coronavirus non-structural protein 15 (NSP15 or nsp15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain exhibits endoribonuclease activity designated EndoU, highly conserved in all known CoVs and is part of the replicase-transcriptase complex that plays important roles in virus replication and transcription [1, 2, 3]. NSP15 is a Uridylate-specific endoribonuclease that cleaves the 5'-polyuridines from negative-sense viral RNA, termed PUN RNA either upstream or downstream of uridylates, at GUU or GU to produce molecules with 2',3'-cyclic phosphate ends [2, 3]. PUN RNA is a CoV MDA5-dependent pathogen-associated molecular pattern (PAMP) [3].
Domain
A, B
PF19216Coronavirus replicase NSP15, middle domain (CoV_NSP15_M)Coronavirus replicase NSP15, middle domainThis entry represents the non-catalytic middle domain from coronavirus non-structural protein 15 (NSP15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain is formed by ten beta strands organised in ...This entry represents the non-catalytic middle domain from coronavirus non-structural protein 15 (NSP15). NSP15 is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. This domain is formed by ten beta strands organised into three beta hairpins [1, 2].
Domain
A, B
PF19219Coronavirus replicase NSP15, N-terminal oligomerisation (CoV_NSP15_N)Coronavirus replicase NSP15, N-terminal oligomerisationThis is the N-terminal domain of the coronavirus nonstructural protein 15 (NSP15), which is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. NSP15, is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) carryi ...This is the N-terminal domain of the coronavirus nonstructural protein 15 (NSP15), which is encoded by ORF1a/1ab and proteolytically released from the pp1a/1ab polyprotein. NSP15, is a nidoviral RNA uridylate-specific endoribonuclease (NendoU) carrying C-terminal catalytic domain belonging to the EndoU family. The SARS-CoV-2 NendoU monomers assemble into a double-ring hexamer, generated by a dimer of trimers. The hexamer is stabilized by the interactions of N-terminal oligomerization domain.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Uridylate-specific endoribonuclease

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
A, B
IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
A, B
IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
A, B
IPR044315Nonstructural protein 14, betacoronavirusDomain
A, B
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A, B
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A, B
IPR046441RNA-dependent RNA polymerase, coronavirusDomain
A, B
IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
A, B
IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
A, B
IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
A, B
IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
A, B
IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
A, B
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B
IPR013016Peptidase C16, coronavirusDomain
A, B
IPR009466Non-structural protein 14, coronavirusDomain
A, B
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A, B
IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
A, B
IPR047570NSP12, interface domain, coronavirusDomain
A, B
IPR018995RNA synthesis protein NSP10, coronavirusDomain
A, B
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A, B
IPR050534Coronaviruses polyprotein 1abFamily
A, B
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
A, B
IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
A, B
IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
A, B
IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
A, B
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
A, B
IPR014828Non-structural protein NSP7, coronavirusDomain
A, B
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
A, B
IPR014829Non-structural protein NSP8, coronavirusDomain
A, B
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A, B
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, B
IPR044389Non-structural protein 2, SARS-CoV-likeDomain
A, B
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, B
IPR008740Peptidase C30, coronavirusDomain
A, B
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A, B
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A, B
IPR049894Coronavirus NSP3, 3Ecto domainDomain
A, B
IPR043472Macro domain-likeHomologous Superfamily
A, B
IPR043609NendoU domain, nidovirusDomain
A, B
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
A, B
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A, B
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
A, B
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A, B
IPR044351RNA-dependent RNA polymerase, SARS-CoV-likeDomain
A, B
IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
A, B
IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
A, B
IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
A, B
IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
A, B
IPR043611Coronavirus replicase NSP3, C-terminalDomain
A, B
IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
A, B
IPR047566Coronavirus replicase NSP3, Y domainDomain
A, B
IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
A, B
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A, B
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B
IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
A, B
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A, B
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A, B
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A, B
IPR043610Non-structural protein 6, coronavirusDomain
A, B
IPR027351(+) RNA virus helicase core domainDomain
A, B
IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
A, B
IPR009461Non-structural protein NSP16, coronavirus-likeDomain
A, B
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A, B
IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
A, B
IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
A, B
IPR044401NSP15, NendoU domain, coronavirusDomain
A, B
IPR014822Non-structural protein NSP9, coronavirusDomain
A, B
IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
A, B
IPR021590NSP1, globular domain, betacoronavirusDomain
A, B
IPR044367Non-structural protein 6, betacoronavirusDomain
A, B
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A, B
IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
A, B
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A, B
IPR046438Nidovirus 2-O-methyltransferaseDomain
A, B
IPR002589Macro domainDomain
A, B
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
A, B
IPR044371Non-structural protein 3, X-domain-likeDomain
A, B
IPR007094RNA-directed RNA polymerase, catalytic domainDomain